4FNX - chain A | Anaplastic lymphoma receptor tyrosine kinase
Structure information
| PDB: | 4FNX |
| PubMed: | 22932897 |
| Release date: | 2012-08-29 |
| Resolution: | 1.7 Å |
| Kinase: | ALK |
| Family: | ALK |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 5.6 |
| Missing Residues: | 6 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.9Å) |
| ASP rotation (xDFG.81) : | 10° |
| PHE rotation (xDFG.82) : | 15° |
| Activation loop position: | -4.6Å |
| αC-helix position: | 17.2Å |
| G-rich loop angle: | - |
| G-rich loop distance: | - |
| G-rich loop rotation: | - |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I2
No H-bonds
I6
No H-bonds
I9
No H-bonds
Binding pocket sequence
| Uniprot | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
| Structure: | RGL______EVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Modified residues
No modified residues identified.