Navigate through KLIFS

Search by ligand

SMILES:

Type of search:

Include tautomers

Search by classification:

Kinase (HGNC):
Family:
Group:
Organism:


Search by structural annotation:

DFG conformation:
αC-helix conformation:
Ligand-bound:
Include deprecated structures

Search by ligand binding mode:

Main pocket:
Front cleft
Gate area
Back cleft

Subpockets :

Front pocket I
Front pocket II
Back pocket I A
Back pocket I B
Back pocket II-in
Back pocket IIA-in
Back pocket IIB-in
Back pocket II-out
Back pocket IIB
Back pocket III
Back pocket IV
Back pocket V

Search by pocket waters:

I1
I2
I3
I4
I5
I6
I7
I8
I9
I10
I11
O1
O2

Search by structure properties:

Min:Max:
X-ray resolution
Quality score
G-rich loop angle:
G-rich loop rotation
G-rich loop distance:
Release date:

Search by ligand properties:

Min:Max:
Molecular Weight
LogP
Hydrogen Donors
Hydrogen Acceptors
Heavy Atoms
Rotatable Bonds
Rings

Search by binding pocket composition (sequence):

Match wild type sequence only
I g.l II III αC
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
αC b.l IV
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
IV V GK hinge linker αD αE
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
αE VI c.l VII VIII x
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
DFG a.l
81
82
83
84
85

Search by ligand-kinase interaction pattern:
(* = Any interaction, H = H-bond, A = Aromatic, I = Ionic, X = No interaction)

I g.l II III αC
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
αC b.l IV
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
IV V GK hinge linker αD αE
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
αE VI c.l VII VIII x
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
DFG a.l
81
82
83
84
85