2YJS - chain A | Anaplastic lymphoma receptor tyrosine kinase
Structure information
| PDB: | 2YJS |
| PubMed: | - |
| Release date: | 2012-06-06 |
| Resolution: | 1.9 Å |
| Kinase: | ALK |
| Family: | ALK |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 6.4 |
| Missing Residues: | 4 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (3.8Å) |
| ASP rotation (xDFG.81) : | 2° |
| PHE rotation (xDFG.82) : | 17° |
| Activation loop position: | -4.3Å |
| αC-helix position: | 17Å |
| G-rich loop angle: | - |
| G-rich loop distance: | - |
| G-rich loop rotation: | - |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I3
No H-bonds
I5
H-bond protein
I6
H-bond protein
Binding pocket sequence
| Uniprot | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
| Structure: | RGLGH____EVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Modified residues
No modified residues identified.