5VC3 - chain A | WEE1 G2 checkpoint kinase
Structure information
PDB: | 5VC3 |
PubMed: | 28792760 |
Release date: | 2017-08-23 |
Resolution: | 1.97 Å |
Kinase: | WEE1 (Wee1) |
Family: | WEE |
Group: | Other |
Species: | HUMAN |
Quality Score: | 8 |
Missing Residues: | 0 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | No (5.3Å) |
ASP rotation (xDFG.81) : | 339° |
PHE rotation (xDFG.82) : | 342° |
Activation loop position: | -3.3Å |
αC-helix position: | 17.1Å |
G-rich loop angle: | 58.1° |
G-rich loop distance: | 17.2Å |
G-rich loop rotation: | 41.4° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I2
H-bond protein
I4
H-bond protein
I5
H-bond ligand
H-bond protein
Binding pocket sequence
Uniprot | EKIGSGEFGSVFKYAIKRSNALREVYAHAVLGSHVVRYFSALIQNEYCNGGSLADAISEYIHSMSLVHMDIKPSNIFIIGDLGHV |
Structure: | EKIGSGEFGSVFKYAIKRSNALREVYAHAVLGSHVVRYFSALIQNEYCNGGSLADAISEYIHSMSLVHMDIKPSNIFIIGDLGHV |
Modified residues
No modified residues identified.
Orthosteric ligand
Ligand HET-code: DB8
Ligand Name: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
Main pockets | |
---|---|
Front | |
Gate | |
Back |
Subpockets | |
---|---|
FP-I | |
FP-II | |
BP-I-A | |
BP-I-B | |
BP-II-in | |
BP-II-A-in | |
BP-II-B-in | |
BP-II-out | |
BP-II-B | |
BP-III | |
BP-IV | |
BP-V |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
I | g.l | II | III | αC | |||||||||||||||
1 E 303 | 2 K 304 | 3 I 305 | 4 G 306 | 5 S 307 | 6 G 308 | 7 E 309 | 8 F 310 | 9 G 311 | 10 S 312 | 11 V 313 | 12 F 314 | 13 K 315 | 14 Y 325 | 15 A 326 | 16 I 327 | 17 K 328 | 18 R 329 | 19 S 330 | 20 N 342 |
■ | ■ | ■ | ■ | ■ | ■ | ||||||||||||||
αC | b.l | IV | |||||||||||||||||
21 A 343 | 22 L 344 | 23 R 345 | 24 E 346 | 25 V 347 | 26 Y 348 | 27 A 349 | 28 H 350 | 29 A 351 | 30 V 352 | 31 L 353 | 32 G 354 | 33 S 357 | 34 H 358 | 35 V 359 | 36 V 360 | 37 R 361 | 38 Y 362 | 39 F 363 | 40 S 364 |
■ | |||||||||||||||||||
IV | V | GK | hinge | linker | αD | αE | |||||||||||||
41 A 365 | 42 L 373 | 43 I 374 | 44 Q 375 | 45 N 376 | 46 E 377 | 47 Y 378 | 48 C 379 | 49 N 380 | 50 G 381 | 51 G 382 | 52 S 383 | 53 L 384 | 54 A 385 | 55 D 386 | 56 A 387 | 57 I 388 | 58 S 389 | 59 E 390 | 60 Y 416 |
■ | ■ | ■ | ■▲ | ■ | ■ | ■ | |||||||||||||
αE | VI | c.l | VII | VIII | x | ||||||||||||||
61 I 417 | 62 H 418 | 63 S 419 | 64 M 420 | 65 S 421 | 66 L 422 | 67 V 423 | 68 H 424 | 69 M 425 | 70 D 426 | 71 I 427 | 72 K 428 | 73 P 429 | 74 S 430 | 75 N 431 | 76 I 432 | 77 F 433 | 78 I 434 | 79 I 461 | 80 G 462 |
■ | ■♦♦ | ||||||||||||||||||
DFG | a.l | ||||||||||||||||||
81 D 463 | 82 L 464 | 83 G 465 | 84 H 466 | 85 V 467 | |||||||||||||||
■ |
Binding affinities
ChEMBL ID:CHEMBL288441Bioaffinities: 409 records for 200 kinase(s)
Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
---|---|---|---|---|---|---|
Homo sapiens | Adaptor-associated kinase | 5.6 | 5.6 | 5.8 | pKd | 2 |
Homo sapiens | ALK tyrosine kinase receptor | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | BMP-2-inducible protein kinase | 6.1 | 6.1 | 6.5 | pKd | 2 |
Homo sapiens | Bone morphogenetic protein receptor type-2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Breakpoint cluster region protein | 8.5 | 8.5 | 8.5 | pKd | 2 |
Homo sapiens | CaM kinase I delta | 7 | 7 | 7 | pIC50 | 1 |
Homo sapiens | CaM kinase I delta | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | CaM kinase II alpha | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | CaM kinase II gamma | 6.7 | 6.7 | 6.7 | pIC50 | 1 |
Homo sapiens | CaM kinase II gamma | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | CaM-kinase kinase beta | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Casein kinase I alpha | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Casein kinase I delta | 5.5 | 5.5 | 6.6 | pKd | 2 |
Homo sapiens | Casein kinase I epsilon | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Casein kinase I isoform alpha-like | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Citron Rho-interacting kinase | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Cyclin-dependent kinase 7 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Discoidin domain-containing receptor 2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
Homo sapiens | Dual serine/threonine and tyrosine protein kinase | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 9 | 9 | 9 | pIC50 | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 5.4 | 5.4 | 7.7 | pKd | 2 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 5.9 | 5.9 | 8 | pKd | 2 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 5.8 | 5.8 | 8.1 | pKd | 2 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 6 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 7 | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Dual specificity protein kinase CLK2 | 5.8 | 5.8 | 5.8 | pKd | 2 |
Homo sapiens | Dual specificity protein kinase CLK3 | 6.5 | 6.5 | 6.5 | pKd | 2 |
Homo sapiens | Dual specificity protein kinase CLK4 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Dual specificty protein kinase CLK1 | 6.2 | 6.2 | 6.2 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 2 | 6.9 | 6.9 | 7.8 | pKd | 2 |
Homo sapiens | Ephrin type-A receptor 3 | 8.2 | 8.2 | 8.2 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 4 | 7.2 | 7.2 | 7.8 | pKd | 2 |
Homo sapiens | Ephrin type-A receptor 5 | 7.6 | 7.6 | 7.6 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 6 | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 8 | 8.1 | 8.1 | 8.1 | pKd | 1 |
Homo sapiens | Ephrin type-B receptor 1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
Homo sapiens | Ephrin type-B receptor 2 | 8.1 | 8.1 | 8.1 | pIC50 | 1 |
Homo sapiens | Ephrin type-B receptor 2 | 6.6 | 6.6 | 8.1 | pKd | 2 |
Homo sapiens | Ephrin type-B receptor 3 | 5.8 | 5.8 | 6.7 | pKd | 2 |
Homo sapiens | Ephrin type-B receptor 4 | 8.3 | 8.3 | 8.3 | pIC50 | 1 |
Homo sapiens | Ephrin type-B receptor 4 | 7 | 7 | 8 | pKd | 2 |
Homo sapiens | Ephrin type-B receptor 6 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 6.3 | 6.3 | 7.3 | pIC50 | 2 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 7.5 | 6.4 | 7.8 | pKd | 13 |
Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Focal adhesion kinase 1 | 6.3 | 6.3 | 6.3 | pIC50 | 1 |
Homo sapiens | Focal adhesion kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 2 |
Homo sapiens | G protein-coupled receptor kinase 4 | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | G protein-coupled receptor kinase 7 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Hepatocyte growth factor receptor | 5.5 | 5.2 | 5.7 | pKd | 3 |
Homo sapiens | Homeodomain-interacting protein kinase 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Homeodomain-interacting protein kinase 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Homeodomain-interacting protein kinase 3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Homeodomain-interacting protein kinase 4 | 6.9 | 6.9 | 6.9 | pKd | 1 |
Homo sapiens | Hormonally up-regulated neu tumor-associated kinase | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 6.1 | 6.1 | 7.3 | pKd | 2 |
Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 6.2 | 6.2 | 6.2 | pIC50 | 1 |
Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 6.1 | 6.1 | 6.3 | pKd | 2 |
Homo sapiens | Leukocyte tyrosine kinase receptor | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Macrophage colony stimulating factor receptor | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Macrophage-stimulating protein receptor | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Microtubule-associated serine/threonine-protein kinase 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Misshapen-like kinase 1 | 7.7 | 7.7 | 7.7 | pIC50 | 1 |
Homo sapiens | Misshapen-like kinase 1 | 8.5 | 8.5 | 8.5 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase 7 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 1 | 5.4 | 5.4 | 7 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 11 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 12 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 6.2 | 6.2 | 7.5 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 5.9 | 5.9 | 7.3 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 4 | 5.8 | 5.8 | 7 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 6.1 | 6.1 | 7.8 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 8 | 8 | 8 | pIC50 | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 7.1 | 7.1 | 8.5 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 7.2 | 7.2 | 8.3 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 8.1 | 8.1 | 8.1 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 9.5 | 9.5 | 9.5 | pIC50 | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 7.8 | 7.8 | 9.3 | pKd | 2 |
Homo sapiens | Mixed lineage kinase 7 | 5.9 | 5.9 | 7.1 | pKd | 2 |
Homo sapiens | Myosin IIIA | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Myosin-IIIB | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Myosin light chain kinase, smooth muscle | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Myotonin-protein kinase | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Nerve growth factor receptor Trk-A | 7.7 | 7.7 | 7.7 | pIC50 | 1 |
Homo sapiens | Nerve growth factor receptor Trk-A | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 7.6 | 7.6 | 7.6 | pIC50 | 1 |
Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | NT-3 growth factor receptor | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | NUAK family SNF1-like kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | NUAK family SNF1-like kinase 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
Homo sapiens | Peripheral plasma membrane protein CASK | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Phosphorylase kinase gamma subunit 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Phosphorylase kinase gamma subunit 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Platelet-derived growth factor receptor alpha | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Platelet-derived growth factor receptor beta | 5.6 | 5.6 | 6.7 | pKd | 2 |
Homo sapiens | Protein kinase C delta | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Protein kinase C epsilon | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Protein kinase C nu | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Protein kinase C theta | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Protein kinase N1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Protein kinase N2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Protein tyrosine kinase 2 beta | 6.9 | 6.9 | 6.9 | pIC50 | 1 |
Homo sapiens | Protein tyrosine kinase 2 beta | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 5.6 | 5.6 | 5.6 | pIC50 | 1 |
Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 7.6 | 7.6 | 7.6 | pKd | 1 |
Homo sapiens | Receptor tyrosine-protein kinase erbB-3 | 9.1 | 9.1 | 9.1 | pKd | 1 |
Homo sapiens | Rho-associated protein kinase 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Rho-associated protein kinase 2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Ribosomal protein S6 kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 5.5 | 5.5 | 5.5 | pKd | 2 |
Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Ribosomal protein S6 kinase alpha 6 | 5.6 | 5.6 | 5.6 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase 10 | 7.3 | 7.3 | 7.3 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase 10 | 6.1 | 6.1 | 8.2 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase 2 | 6.1 | 6.1 | 8.3 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase 24 | 8.4 | 8.4 | 8.4 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase 24 | 6.4 | 6.4 | 7.6 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase 25 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase 32A | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase 33 | 7.4 | 7.4 | 7.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase 35 | 8.7 | 8.7 | 8.7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase 36 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase Chk1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase Chk2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase DCLK3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase GAK | 8.9 | 7.4 | 8.9 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase MST1 | 6.7 | 6.7 | 6.7 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase MST1 | 6.7 | 6.7 | 6.7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase MST2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase MST4 | 7.4 | 7.4 | 7.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase Nek11 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase NEK2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase NIM1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Serine/threonine protein kinase NLK | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PAK 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PAK 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PAK 3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PFTAIRE-1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PFTAIRE-2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Mycobacterium tuberculosis | Serine/threonine-protein kinase pknB | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PLK1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PLK2 | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase RIO1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase RIO3 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase RIPK2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase SIK1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.7 | 6.7 | 7.5 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase SIK3 | 6.8 | 6.8 | 7.2 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase SRPK3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO3 | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.3 | 6.3 | 6.3 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase TBK1 | 6 | 6 | 6.6 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase TNNI3K | 6.8 | 6.8 | 6.8 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase tousled-like 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase tousled-like 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase ULK1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase ULK2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase ULK3 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase VRK2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase WEE1 | 6.3 | 5.7 | 7.1 | pKd | 3 |
Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 7.8 | 7.8 | 7.8 | pKd | 1 |
Homo sapiens | STE20/SPS1-related proline-alanine-rich protein kinase | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Stem cell growth factor receptor | 6.7 | 5.2 | 7.5 | pIC50 | 5 |
Homo sapiens | Stem cell growth factor receptor | 6.6 | 6.3 | 7.1 | pKd | 7 |
Homo sapiens | Testis-specific serine/threonine-protein kinase 1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | TRAF2- and NCK-interacting kinase | 7.5 | 7.5 | 7.6 | pKd | 2 |
Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 6.2 | 6.2 | 6.9 | pIC50 | 4 |
Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 6.5 | 6.1 | 6.6 | pKd | 3 |
Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 6.5 | 6.5 | 7.9 | pKi | 5 |
Homo sapiens | Tyrosine kinase non-receptor protein 2 | 8.6 | 8.6 | 8.6 | pIC50 | 2 |
Homo sapiens | Tyrosine kinase non-receptor protein 2 | 6.9 | 6.9 | 7.5 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase ABL | 9 | 6.3 | 9.3 | pIC50 | 6 |
Homo sapiens | Tyrosine-protein kinase ABL | 10.1 | 7.7 | 10.5 | pKd | 17 |
Homo sapiens | Tyrosine-protein kinase ABL2 | 9.3 | 9.3 | 9.3 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase ABL2 | 7.7 | 7.7 | 8.8 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase BLK | 8.5 | 8.5 | 8.5 | pKd | 1 |
Mus musculus | Tyrosine-protein kinase BLK | 8.1 | 8.1 | 8.1 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase BMX | 8.1 | 8.1 | 9 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase BMX | 6.7 | 6.7 | 6.7 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase BTK | 8.6 | 8.6 | 8.6 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase BTK | 7.6 | 7.6 | 8.3 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase CSK | 7.2 | 7.2 | 7.2 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase CSK | 6.7 | 6.7 | 7.5 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase CTK | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase FER | 6.3 | 6.3 | 6.3 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase FER | 6.1 | 6.1 | 6.4 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase FES | 6.5 | 6.5 | 6.5 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase FES | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase FGR | 9 | 9 | 9 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase FGR | 8.2 | 8.2 | 8.2 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase FRK | 8.7 | 8.7 | 8.7 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase FRK | 7.6 | 7.6 | 8.9 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase FYN | 6.4 | 6.4 | 8.7 | pIC50 | 3 |
Homo sapiens | Tyrosine-protein kinase FYN | 6.8 | 6.8 | 8 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase HCK | 8.5 | 8.5 | 8.5 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase HCK | 8.5 | 6.9 | 8.5 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase ITK/TSK | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase JAK2 | 6 | 6 | 6 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase JAK3 | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase LCK | 8.9 | 8.9 | 8.9 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase LCK | 7.5 | 7.5 | 9.2 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase Lyn | 8.1 | 8.1 | 8.1 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase Lyn | 7.2 | 7.2 | 8.4 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 5.7 | 5.5 | 6 | pKd | 7 |
Homo sapiens | Tyrosine-protein kinase receptor RET | 5.4 | 5.3 | 5.4 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 7.2 | 7.2 | 7.2 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase receptor UFO | 6.3 | 6.3 | 6.8 | pIC50 | 4 |
Homo sapiens | Tyrosine-protein kinase receptor UFO | 7.3 | 7.3 | 7.3 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase SRC | 8.4 | 7 | 9 | pIC50 | 32 |
Homo sapiens | Tyrosine-protein kinase SRC | 9 | 6.8 | 9 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase Srms | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase SYK | 7.3 | 7.3 | 7.3 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase SYK | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase TEC | 6.6 | 6.6 | 6.6 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase TEC | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase TXK | 7.4 | 7.4 | 7.4 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase TXK | 7.1 | 7.1 | 7.1 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase TYK2 | 5.2 | 5.2 | 5.4 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase YES | 9.4 | 9.4 | 9.4 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase YES | 6.8 | 6.8 | 8.4 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase ZAP-70 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Wee1-like protein kinase 2 | 7 | 7 | 7 | pKd | 2 |