1YI6 - chain A | SRC proto-oncogene, non-receptor tyrosine kinase
Structure information
| PDB: | 1YI6 |
| PubMed: | - |
| Release date: | 2006-05-02 |
| Resolution: | 2 Å |
| Kinase: | SRC |
| Family: | Src |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.7Å) |
| ASP rotation (xDFG.81) : | 349° |
| PHE rotation (xDFG.82) : | 1° |
| Activation loop position: | -3.2Å |
| αC-helix position: | 15.7Å |
| G-rich loop angle: | 64.3° |
| G-rich loop distance: | 20Å |
| G-rich loop rotation: | 36° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I3
No H-bonds
I4
H-bond protein
I5
No H-bonds
I6
No H-bonds
I9
No H-bonds
I10
H-bond protein
Binding pocket sequence
| Uniprot | VKLGQGCFGEVWMVAIKTLAFLQEAQVMKKLREKLVQLYAVYIVTEYMSKGSLLDFLKGYVERMNYVHRDLRAANILVVADFGLA |
| Structure: | VKLGQGCFGEVWMVAIKTLAFLQEAQVMKKLREKLVQLYAVYIVTEYMSKGSLLDFLKGYVERMNYVHRDLRAANILVVADFGLA |
Modified residues
Residue 335 (V.42)
Phosphorylated tyrosine
Residue 416 (not in pocket)
Phosphorylated tyrosine