1FMK - chain A | SRC proto-oncogene, non-receptor tyrosine kinase
Structure information
| PDB: | 1FMK |
| PubMed: | 9024657 |
| Release date: | 1997-08-20 |
| Resolution: | 1.5 Å |
| Kinase: | SRC |
| Family: | Src |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | out |
| Salt bridge KIII.17 and EαC.24: | No (12.1Å) |
| ASP rotation (xDFG.81) : | 336° |
| PHE rotation (xDFG.82) : | 3° |
| Activation loop position: | -4Å |
| αC-helix position: | 20.5Å |
| G-rich loop angle: | 50.5° |
| G-rich loop distance: | 15Å |
| G-rich loop rotation: | 46° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I2
H-bond protein
I4
No H-bonds
I5
H-bond protein
I6
H-bond protein
I8
H-bond protein
I9
No H-bonds
I11
H-bond protein
Binding pocket sequence
| Uniprot | VKLGQGCFGEVWMVAIKTLAFLQEAQVMKKLREKLVQLYAVYIVTEYMSKGSLLDFLKGYVERMNYVHRDLRAANILVVADFGLA |
| Structure: | VKLGQGCFGEVWMVAIKTLAFLQEAQVMKKLREKLVQLYAVYIVTEYMSKGSLLDFLKGYVERMNYVHRDLRAANILVVADFGLA |
Modified residues
Residue 527 (not in pocket)
Phosphorylated tyrosine