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Search results (176 entries covering 89 PDB structures)
#
Kinase
Family
Group
PDB
Chain
(Alternate) Model
Orthosteric ligand
Organism
Details
Similarity (MFP)
File
IRAK4
IRAK
TKL
4u9a
A
staurosporine
Human
1751
0.64
IRAK4
IRAK
TKL
4u9a
B
staurosporine
Human
1792
0.64
SYK
Syk
TK
1xbc
A
A
staurosporine
Human
1165
0.64
DYRK1A
DYRK
CMGC
4nct
A
pkc412
Human
3794
0.62
IRAK4
IRAK
TKL
2oic
A
staurosporine
Human
1739
0.64
ERN1 (IRE1)
IRE
Other
4yzc
B
B
staurosporine
Human
6231
0.64
STK16 (MPSK1)
NAK
Other
2buj
A
staurosporine
Human
2229
0.64
MAP3K5
STE11
STE
4bf2
A
staurosporine
Human
4743
0.64
LCK
Src
TK
1qpj
A
staurosporine
Human
2283
0.64
CSK
Csk
TK
1byg
A
staurosporine
Human
2943
0.64
STK16 (MPSK1)
NAK
Other
2buj
B
staurosporine
Human
2230
0.64
MAP3K5
STE11
STE
2clq
B
B
staurosporine
Human
4732
0.64
IRAK4
IRAK
TKL
2oic
D
staurosporine
Human
1755
0.64
EPHB4 (EphB4)
Eph
TK
2yn8
B
staurosporine
Human
349
0.64
CHEK1 (CHK1)
CAMKL
CAMK
7ako
B
A
staurosporine
Human
13492
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b1u
C
A
staurosporine
Human
9847
0.64
PIK3CG (p110g)
PIK
Atypical
1e8z
A
staurosporine
Human
9228
0.64
MAP3K5
STE11
STE
2clq
A
B
staurosporine
Human
4736
0.64
EGFR
EGFR
TK
5xgn
A
12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole
Human
8553
0.43
EGFR
EGFR
TK
5xgm
A
12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole
Human
8552
0.43
LIMK1
LISK
TKL
3s95
A
A
staurosporine
Human
1246
0.64
IRAK4
IRAK
TKL
2nry
D
A
staurosporine
Human
1789
0.64
LIMK1
LISK
TKL
3s95
A
B
staurosporine
Human
1248
0.64
PDPK1 (PDK1)
PDK1
AGC
1okz
A
7-hydroxystaurosporine
Human
3209
0.47
PRKAA1 (AMPKa1)
CAMKL
CAMK
6c9j
A
staurosporine
Human
10717
0.64
PRKAA1 (AMPKa1)
CAMKL
CAMK
4rer
A
staurosporine
Human
121
0.64
PRKAA1 (AMPKa1)
CAMKL
CAMK
4rew
A
staurosporine
Human
124
0.64
PRKAA1 (AMPKa1)
CAMKL
CAMK
6c9g
A
staurosporine
Human
10715
0.64
PRKAA1 (AMPKa1)
CAMKL
CAMK
6c9h
A
staurosporine
Human
10714
0.64
PRKAA1 (AMPKa1)
CAMKL
CAMK
6c9f
A
staurosporine
Human
10716
0.64
IRAK4
IRAK
TKL
2nry
B
A
staurosporine
Human
1758
0.64
PDPK1 (PDK1)
PDK1
AGC
1oky
A
A
staurosporine
Human
3164
0.64
Prkaa1 (AMPKa1)
CAMKL
CAMK
5ufu
A
staurosporine
Mouse
7590
0.64
CDK2
CDK
CMGC
4ez7
A
staurosporine
Human
4240
0.64
PAK4
STE20
STE
5ved
A
staurosporine
Human
8570
0.64
ERN1 (IRE1)
IRE
Other
4yzc
A
A
staurosporine
Human
6235
0.64
IRAK4
IRAK
TKL
2nry
C
A
staurosporine
Human
1779
0.64
GSK3B
GSK
CMGC
1q3d
B
staurosporine
Human
752
0.64
TGFBR1 (TGFbR1)
STKR
TKL
5e8w
A
A
staurosporine
Human
6611
0.64
MAP2K1
STE7
STE
3eqf
A
k-252a
Human
3317
1.00
EPHB4 (EphB4)
Eph
TK
2yn8
A
staurosporine
Human
352
0.64
EPHB4 (EphB4)
Eph
TK
3zew
B
B
staurosporine
Human
357
0.64
SYK
Syk
TK
1xbc
A
B
staurosporine
Human
1207
0.64
DYRK1A
DYRK
CMGC
4nct
C
pkc412
Human
3779
0.62
PKN1
PKN
AGC
4otg
A
A
lestaurtinib
Human
548
0.49
STK32A (YANK1)
YANK
AGC
4fr4
A
B
staurosporine
Human
4690
0.64
CHEK1 (CHK1)
CAMKL
CAMK
7ako
A
B
staurosporine
Human
13495
0.64
ERN1 (IRE1)
IRE
Other
4yzc
A
B
staurosporine
Human
6232
0.64
CHEK1 (CHK1)
CAMKL
CAMK
5oor
A
staurosporine
Human
8603
0.64
RIPK2
RIPK
TKL
5ng2
A
B
staurosporine
Human
8056
0.64
RIPK2
RIPK
TKL
5ng2
A
A
staurosporine
Human
8050
0.64
CHEK1 (CHK1)
CAMKL
CAMK
1nvs
A
rel-(9r,12s)-9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2h)-dione
Human
1591
0.43
CHEK1 (CHK1)
CAMKL
CAMK
1nvr
A
staurosporine
Human
1585
0.64
CDK2
CDK
CMGC
7nvq
A
staurosporine
Human
13627
0.64
STK24 (MST3)
STE20
STE
3ckx
A
staurosporine
Human
5599
0.64
STK24 (MST3)
STE20
STE
4qmy
A
staurosporine
Human
5592
0.64
RPS6KA1 (RSK3)
RSK
AGC
2z7r
A
staurosporine
Human
2777
0.64
CHEK1 (CHK1)
CAMKL
CAMK
1nvq
A
7-hydroxystaurosporine
Human
1642
0.47
MELK
CAMKL
CAMK
5m5a
A
A
k-252a
Human
8735
1.00
STK32A (YANK1)
YANK
AGC
4fr4
E
B
staurosporine
Human
4685
0.64
LCK
Src
TK
1qpd
A
staurosporine
Human
2267
0.64
MAP3K5
STE11
STE
2clq
A
A
staurosporine
Human
4740
0.64
MAPKAPK2
MAPKAPK
CAMK
1nxk
A
staurosporine
Human
1342
0.64
CDK2
CDK
CMGC
1pkd
A
7-hydroxystaurosporine
Human
4170
0.47
MKNK2 (MNK2)
MAPKAPK
CAMK
2hw7
A
staurosporine
Human
764
0.64
MAP2K6
STE7
STE
3fme
A
staurosporine
Human
1231
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
5iso
C
staurosporine
Human
7980
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
5ezv
A
A
staurosporine
Human
6424
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b2e
A
staurosporine
Human
9851
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b1u
C
B
staurosporine
Human
9850
0.64
AAK1
NAK
Other
4wsq
B
B
k-252a
Human
3835
1.00
AAK1
NAK
Other
4wsq
A
A
k-252a
Human
3834
1.00
PRKAA2 (AMPKa2)
CAMKL
CAMK
5iso
A
staurosporine
Human
7981
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
5ezv
C
A
staurosporine
Human
6430
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b1u
A
A
staurosporine
Human
9848
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
4cff
C
staurosporine
Human
190
0.64
AAK1
NAK
Other
4wsq
B
A
k-252a
Human
3833
1.00
PRKAA2 (AMPKa2)
CAMKL
CAMK
5ezv
C
B
staurosporine
Human
6426
0.64
TGFBR2 (TGFbR2)
STKR
TKL
5e8y
A
staurosporine
Human
6627
0.64
AAK1
NAK
Other
4wsq
A
B
k-252a
Human
3836
1.00
TTK
TTK
Other
3hmo
A
staurosporine
Human
4707
0.64
MELK
CAMKL
CAMK
5m5a
A
B
k-252a
Human
8733
1.00
PIM1
PIM
CAMK
1yhs
A
staurosporine
Human
2444
0.64
FES
Fer
TK
3cd3
A
A
staurosporine
Human
2814
0.64
FES
Fer
TK
3cbl
A
B
staurosporine
Human
2811
0.64
IRAK4
IRAK
TKL
2nry
A
A
staurosporine
Human
1753
0.64
FES
Fer
TK
3bkb
A
B
staurosporine
Human
2813
0.64
FES
Fer
TK
3bkb
A
A
staurosporine
Human
2810
0.64
CDK2
CDK
CMGC
1aq1
A
staurosporine
Human
4267
0.64
FES
Fer
TK
3cd3
A
B
staurosporine
Human
2815
0.64
ERN1 (IRE1)
IRE
Other
4yzc
B
A
staurosporine
Human
6227
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
4cfe
C
staurosporine
Human
192
0.64
EPHB4 (EphB4)
Eph
TK
3zew
A
B
staurosporine
Human
377
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
4cff
A
staurosporine
Human
191
0.64
EPHB4 (EphB4)
Eph
TK
3zew
B
A
staurosporine
Human
351
0.64
CDK2
CDK
CMGC
1pkd
C
7-hydroxystaurosporine
Human
3973
0.47
Ripk4 (ANKRD3)
RIPK
TKL
5wnj
A
lestaurtinib
Mouse
9893
0.49
CDK2
CDK
CMGC
4erw
A
staurosporine
Human
4370
0.64
Ripk4 (ANKRD3)
RIPK
TKL
5wnl
A
staurosporine
Mouse
9891
0.64
LYN
Src
TK
3a4o
X
staurosporine
Human
1812
0.64
ZAP70
Syk
TK
1u59
A
A
staurosporine
Human
2734
0.64
ZAP70
Syk
TK
1u59
A
B
staurosporine
Human
2733
0.64
DYRK1A
DYRK
CMGC
4nct
D
pkc412
Human
3751
0.62
DYRK1A
DYRK
CMGC
4nct
B
pkc412
Human
3743
0.62
JAK2
JakA
TK
8bpw
A
A
lestaurtinib
Human
15044
0.49
JAK2
JakA
TK
8bpw
A
B
lestaurtinib
Human
15039
0.49
RIPK2
RIPK
TKL
5ng2
B
A
staurosporine
Human
8053
0.64
IRAK4
IRAK
TKL
4u97
A
staurosporine
Human
1754
0.64
RIPK2
RIPK
TKL
5ng2
B
B
staurosporine
Human
8052
0.64
JAK3
JakA
TK
1yvj
A
A
1,2,3,4-tetrahydrogen-staurosporine
Human
460
0.54
MASTL
MAST
AGC
5loh
B
A
staurosporine
Human
7088
0.64
MASTL
MAST
AGC
5loh
B
B
staurosporine
Human
7087
0.64
MASTL
MAST
AGC
5loh
A
B
staurosporine
Human
7085
0.64
MASTL
MAST
AGC
5loh
A
A
staurosporine
Human
7086
0.64
FES
Fer
TK
3cbl
A
A
staurosporine
Human
2808
0.64
ABL1
Abl
TK
2hz4
B
1,2,3,4-tetrahydrogen-staurosporine
Human
1058
0.54
JAK3
JakA
TK
1yvj
A
B
1,2,3,4-tetrahydrogen-staurosporine
Human
451
0.54
GSK3B
GSK
CMGC
1q3d
A
staurosporine
Human
705
0.64
ALK
ALK
TK
3lcs
A
A
staurosporine
Human
5381
0.64
MAP3K5
STE11
STE
2clq
B
A
staurosporine
Human
4755
0.64
MAP3K5
STE11
STE
4bf2
B
staurosporine
Human
4745
0.64
ALK
ALK
TK
3lcs
A
B
staurosporine
Human
5376
0.64
TGFBR1 (TGFbR1)
STKR
TKL
5e8x
A
B
staurosporine
Human
6617
0.64
STK32A (YANK1)
YANK
AGC
4fr4
C
A
staurosporine
Human
4684
0.64
STK32A (YANK1)
YANK
AGC
4fr4
B
A
staurosporine
Human
4692
0.64
PDPK1 (PDK1)
PDK1
AGC
1oky
A
B
staurosporine
Human
3195
0.64
IRAK4
IRAK
TKL
4u97
B
staurosporine
Human
1742
0.64
IRAK4
IRAK
TKL
2oic
B
staurosporine
Human
1752
0.64
LIMK1
LISK
TKL
3s95
B
B
staurosporine
Human
1247
0.64
LIMK1
LISK
TKL
3s95
B
A
staurosporine
Human
1245
0.64
PRKCQ (PKCt)
PKC
AGC
1xjd
A
staurosporine
Human
5357
0.64
ITK
Tec
TK
1sm2
A
staurosporine
Human
74
0.64
ITK
Tec
TK
1snu
A
staurosporine
Human
82
0.64
IRAK4
IRAK
TKL
2nry
D
B
staurosporine
Human
1746
0.64
ITK
Tec
TK
1sm2
B
staurosporine
Human
73
0.64
IRAK4
IRAK
TKL
2nry
C
B
staurosporine
Human
1750
0.64
ITK
Tec
TK
1snu
B
staurosporine
Human
33
0.64
CHEK1 (CHK1)
CAMKL
CAMK
7ako
A
A
staurosporine
Human
13490
0.64
IRAK4
IRAK
TKL
2nry
B
B
staurosporine
Human
1772
0.64
IRAK4
IRAK
TKL
2oic
C
staurosporine
Human
1734
0.64
IRAK4
IRAK
TKL
2nry
A
B
staurosporine
Human
1777
0.64
STK32A (YANK1)
YANK
AGC
4fr4
B
B
staurosporine
Human
4695
0.64
PKN1
PKN
AGC
4otg
A
B
lestaurtinib
Human
549
0.49
STK32A (YANK1)
YANK
AGC
4fr4
F
B
staurosporine
Human
4686
0.64
CSK
Csk
TK
3d7t
A
staurosporine
Human
2941
0.64
DAPK1
DAPK
CAMK
1wvy
A
staurosporine
Human
5661
0.64
STK32A (YANK1)
YANK
AGC
4fr4
E
A
staurosporine
Human
4689
0.64
STK32A (YANK1)
YANK
AGC
4fr4
C
B
staurosporine
Human
4694
0.64
STK32A (YANK1)
YANK
AGC
4fr4
D
A
staurosporine
Human
4688
0.64
STK32A (YANK1)
YANK
AGC
4fr4
F
A
staurosporine
Human
4691
0.64
EPHB4 (EphB4)
Eph
TK
3zew
A
A
staurosporine
Human
373
0.64
STK32A (YANK1)
YANK
AGC
4fr4
D
B
staurosporine
Human
4687
0.64
CHEK1 (CHK1)
CAMKL
CAMK
7ako
B
B
staurosporine
Human
13496
0.64
STK32A (YANK1)
YANK
AGC
4fr4
A
A
staurosporine
Human
4693
0.64
MAPKAPK2
MAPKAPK
CAMK
1nxk
C
staurosporine
Human
1312
0.64
MAPKAPK2
MAPKAPK
CAMK
1nxk
D
staurosporine
Human
1334
0.64
MAPKAPK2
MAPKAPK
CAMK
2pzy
C
staurosporine
Human
1279
0.64
MAPKAPK2
MAPKAPK
CAMK
1nxk
B
staurosporine
Human
1292
0.64
FES
Fer
TK
3bkb
A
C
staurosporine
Human
2812
0.64
PAK1
STE20
STE
2hy8
1
(5s,6r,7r,9r)-12-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9-tetrahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
Human
172
0.42
IKBKB (IKKb)
IKK
Other
4kik
B
A
k-252a
Human
295
1.00
IKBKB (IKKb)
IKK
Other
4kik
B
B
k-252a
Human
293
1.00
IKBKB (IKKb)
IKK
Other
4kik
A
A
k-252a
Human
290
1.00
IKBKB (IKKb)
IKK
Other
4kik
A
B
k-252a
Human
288
1.00
FYN
Src
TK
2dq7
X
staurosporine
Human
1941
0.64
RPS6KB1 (p70S6K)
RSK
AGC
3a61
A
staurosporine
Human
1846
0.64
RPS6KB1 (p70S6K)
RSK
AGC
3a62
A
staurosporine
Human
1867
0.64
TGFBR1 (TGFbR1)
STKR
TKL
5e8x
A
A
staurosporine
Human
6615
0.64
TGFBR1 (TGFbR1)
STKR
TKL
5e8w
A
B
staurosporine
Human
6614
0.64
RPS6KB1 (p70S6K)
RSK
AGC
4rlo
B
staurosporine
Human
7220
0.64
RPS6KB1 (p70S6K)
RSK
AGC
3a60
B
staurosporine
Human
1856
0.64
RPS6KB1 (p70S6K)
RSK
AGC
3a60
A
staurosporine
Human
1852
0.64
MET
Met
TK
1r0p
A
k-252a
Human
2991
1.00
PRKAA2 (AMPKa2)
CAMKL
CAMK
5ezv
A
B
staurosporine
Human
6428
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b1u
A
B
staurosporine
Human
9849
0.64
PRKAA2 (AMPKa2)
CAMKL
CAMK
4cfe
A
staurosporine
Human
195
0.64
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