KLIFS - the structural kinase database

Search results (43 entries covering 15 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
DYRK1A	DYRK	CMGC	6ej4	A		3-(3-pyridin-3-yl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)aniline	Human	10520	0.43
DYRK1A	DYRK	CMGC	6eif	A		4-(3-pyridin-3-yl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide	Human	10534	0.48
CAMKK2 (CaMKK2)	CAMKK	Other	6cmj	B	A	2-(2-methylpropyl)-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9786	0.52
Abl1 (ABL1)	Abl	TK	3dk3	B	B	2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamide	Mouse	5737	0.40
Abl1 (ABL1)	Abl	TK	3dk3	A	A	2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamide	Mouse	5726	0.40
Abl1 (ABL1)	Abl	TK	3dk3	B	A	2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamide	Mouse	5712	0.40
Abl1 (ABL1)	Abl	TK	3dk6	B		2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamide	Mouse	5718	0.40
Abl1 (ABL1)	Abl	TK	3dk7	A		2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamide	Mouse	5704	0.40
Abl1 (ABL1)	Abl	TK	3dk3	A	B	2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamide	Mouse	5729	0.40
Abl1 (ABL1)	Abl	TK	3dk6	A		2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamide	Mouse	5725	0.40
CAMKK2 (CaMKK2)	CAMKK	Other	6cmj	A	B	2-(2-methylpropyl)-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9783	0.52
LIMK1	LISK	TKL	7ats	A		n-[3-[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]benzenesulfonamide	Human	13164	0.40
Abl1 (ABL1)	Abl	TK	3dk7	B		2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamide	Mouse	5714	0.40
JAK3	JakA	TK	7apf	B	B	3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide	Human	13132	0.40
CAMKK2 (CaMKK2)	CAMKK	Other	6bku	A		2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	8687	0.48
DYRK1A	DYRK	CMGC	6eif	B		4-(3-pyridin-3-yl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide	Human	10544	0.48
ABL1	Abl	TK	7cc2	A		[4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1h-pyrrolo[2,3-b]pyridin-3-yl]-2-methyl-phenyl]boronic acid	Human	13620	0.41
DYRK1A	DYRK	CMGC	6eif	C		4-(3-pyridin-3-yl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide	Human	10525	0.48
DYRK1A	DYRK	CMGC	6ej4	D		3-(3-pyridin-3-yl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)aniline	Human	10545	0.43
JAK3	JakA	TK	7apf	A	A	3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide	Human	13141	0.40
JAK3	JakA	TK	7apf	B	A	3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide	Human	13137	0.40
DYRK1A	DYRK	CMGC	6ej4	B		3-(3-pyridin-3-yl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)aniline	Human	10523	0.43
DYRK1A	DYRK	CMGC	6ej4	C		3-(3-pyridin-3-yl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)aniline	Human	10519	0.43
DYRK1A	DYRK	CMGC	6eif	D		4-(3-pyridin-3-yl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide	Human	10532	0.48
CAMKK2 (CaMKK2)	CAMKK	Other	6cmj	A	A	2-(2-methylpropyl)-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9784	0.52
CAMKK1 (CaMKK1)	CAMKK	Other	6cd6	A	B	2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9714	0.48
JAK3	JakA	TK	7apf	A	B	3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide	Human	13130	0.40
CAMKK2 (CaMKK2)	CAMKK	Other	6cmj	B	B	2-(2-methylpropyl)-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9785	0.52
SGK1	SGK	AGC	3hdm	A		4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	3271	0.60
SGK1	SGK	AGC	3hdn	A		[4-(5-naphthalen-2-yl-1h-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid	Human	3270	1.00
INSR	InsR	TK	3eta	B	B	1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea	Human	600	0.48
INSR	InsR	TK	3eta	A	A	1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea	Human	590	0.48
INSR	InsR	TK	3eta	A	B	1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea	Human	579	0.48
INSR	InsR	TK	3eta	B	A	1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea	Human	588	0.48
CAMKK1 (CaMKK1)	CAMKK	Other	6cd6	A	A	2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9716	0.48
CAMKK1 (CaMKK1)	CAMKK	Other	6cd6	C	B	2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9715	0.48
CAMKK1 (CaMKK1)	CAMKK	Other	6cd6	B	B	2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9713	0.48
CAMKK1 (CaMKK1)	CAMKK	Other	6cd6	C	A	2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9711	0.48
CAMKK1 (CaMKK1)	CAMKK	Other	6cd6	B	A	2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9709	0.48
CAMKK1 (CaMKK1)	CAMKK	Other	6cd6	D	A	2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9710	0.48
CAMKK1 (CaMKK1)	CAMKK	Other	6cd6	D	B	2-cyclopentyl-4-(5-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid	Human	9708	0.48
MET	Met	TK	7b3z	A	B	3-[3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one	Human	13186	0.43
MET	Met	TK	7b3z	A	A	3-[3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one	Human	13181	0.43