KLIFS - the structural kinase database

Search results (47 entries covering 23 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MLKL	TKL-Unique	TKL	7mon	A		n-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	13980	0.40
JAK2	JakA	TK	5wev	A	A	n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide	Human	8377	0.44
GSK3B	GSK	CMGC	4ptg	A	A	2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide	Human	735	0.42
TYK2-b	JakB	TK	7k7o	A	A	6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide	Human	13835	0.40
GSK3B	GSK	CMGC	8djd	A	A	2-[(cyclopropanecarbonyl)amino]-n-(5-phenylpyridin-3-yl)pyridine-4-carboxamide	Human	14673	0.50
TYK2-b	JakB	TK	7k7o	A	B	6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide	Human	13837	0.40
GSK3B	GSK	CMGC	4pte	B	A	n-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide	Human	722	0.47
EGFR	EGFR	TK	4rj7	A	B	2,6-dichloro-n-{2-[(2-{[(2s)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide	Human	828	0.51
EGFR	EGFR	TK	4rj7	A	A	2,6-dichloro-n-{2-[(2-{[(2s)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide	Human	793	0.51
GSK3B	GSK	CMGC	4ptg	B	B	2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide	Human	754	0.42
GSK3B	GSK	CMGC	8djd	A	B	2-[(cyclopropanecarbonyl)amino]-n-(5-phenylpyridin-3-yl)pyridine-4-carboxamide	Human	14668	0.50
RIPK3	RIPK	TKL	7mon	B		n-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	13979	0.40
TGFBR1 (TGFbR1)	STKR	TKL	5fri	A	B	n-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide	Human	6893	0.55
ROCK1	DMPK	AGC	2etr	B		(r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) cyclohexanecarboxamide	Human	2704	0.46
JAK2	JakA	TK	4gmy	A		2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	3684	1.00
TYK2	JakA	TK	4gih	A	A	2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	3339	1.00
GSK3B	GSK	CMGC	4ptg	A	B	2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide	Human	634	0.42
AURKA (AurA)	Aur	Other	2np8	A		n-{3-[(4-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]phenyl}cyclopropanecarboxamide	Human	2075	0.50
ROCK1	DMPK	AGC	2etr	A		(r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) cyclohexanecarboxamide	Human	2700	0.46
GSK3B	GSK	CMGC	4pte	A	A	n-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide	Human	716	0.47
JAK2	JakA	TK	4gfm	A	A	2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide	Human	3680	0.40
GSK3B	GSK	CMGC	4ptc	A	A	2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide	Human	664	0.43
GSK3B	GSK	CMGC	5f95	A		2-[(cyclopropylcarbonyl)amino]-n-(4-phenylpyridin-3-yl)pyridine-4-carboxamide	Human	6373	0.47
JAK2	JakA	TK	5wev	A	B	n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide	Human	8376	0.44
GSK3B	GSK	CMGC	4ptc	B	A	2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide	Human	747	0.43
GSK3B	GSK	CMGC	4pte	A	B	n-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide	Human	717	0.47
GSK3B	GSK	CMGC	5f94	B	B	2-[(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4-carboxamide	Human	6371	0.45
GSK3B	GSK	CMGC	4ptg	B	A	2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide	Human	740	0.42
TYK2-b	JakB	TK	4oli	A		2-chloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	2198	0.77
GSK3B	GSK	CMGC	5f94	A	B	2-[(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4-carboxamide	Human	6369	0.45
GSK3B	GSK	CMGC	4ptc	B	B	2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide	Human	758	0.43
GSK3B	GSK	CMGC	5f94	A	A	2-[(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4-carboxamide	Human	6374	0.45
GSK3B	GSK	CMGC	4pte	B	B	n-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide	Human	667	0.47
GSK3B	GSK	CMGC	5f95	B		2-[(cyclopropylcarbonyl)amino]-n-(4-phenylpyridin-3-yl)pyridine-4-carboxamide	Human	6370	0.47
GSK3B	GSK	CMGC	4ptc	A	B	2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide	Human	659	0.43
JAK2	JakA	TK	4gfm	A	B	2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide	Human	3705	0.40
TYK2	JakA	TK	4gj3	A		2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide	Human	3345	0.57
TYK2	JakA	TK	4gfo	A	A	2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide	Human	3336	0.40
TYK2	JakA	TK	5wal	A	B	n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide	Human	8374	0.44
TYK2	JakA	TK	4gj2	A		2,6-dichloro-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide	Human	3344	0.77
TYK2	JakA	TK	4gih	A	B	2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	3332	1.00
TYK2	JakA	TK	4gii	A		2,6-dichloro-4-cyano-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	3331	0.75
TYK2	JakA	TK	4gfo	A	B	2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide	Human	3338	0.40
GSK3B	GSK	CMGC	5f94	B	A	2-[(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4-carboxamide	Human	6372	0.45
TYK2	JakA	TK	5wal	A	A	n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide	Human	8375	0.44
MAPK10 (JNK3)	MAPK	CMGC	2exc	X		n-{2'-[(4-fluorophenyl)amino]-4,4'-bipyridin-2-yl}-4-methoxycyclohexanecarboxamide	Human	3478	0.44
TGFBR1 (TGFbR1)	STKR	TKL	5fri	A	A	n-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide	Human	6894	0.55