| AURKA (AurA) | Aur | Other | 2bmc | C | | (3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamide | Human | 2060 | 0.43 | |
| AURKA (AurA) | Aur | Other | 2bmc | D | | (3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamide | Human | 1984 | 0.43 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 1zys | A | | n-{5-[4-(4-methylpiperazin-1-yl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}nicotinamide | Human | 1655 | 0.53 | |
| AURKA (AurA) | Aur | Other | 2xru | A | | 3-({[4-(4-methylpiperazin-1-yl)phenyl]carbonyl}amino)-n-[(1r)-1-phenylpropyl]-1h-thieno[3,2-c]pyrazole-5-carboxamide | Human | 1954 | 0.40 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq7 | B | B | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8596 | 0.41 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5op2 | A | B | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8611 | 0.41 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq7 | A | A | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8601 | 0.41 | |
| CLK3 | CLK | CMGC | 6rct | B | A | 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{n}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide | Human | 11128 | 0.44 | |
| AURKA (AurA) | Aur | Other | 2bmc | A | | (3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamide | Human | 2015 | 0.43 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq8 | A | | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8606 | 0.41 | |
| EGFR | EGFR | TK | 5em6 | A | | 4-[(2-azanylpyrimidin-4-yl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide | Human | 6305 | 0.42 | |
| CLK1 | CLK | CMGC | 6raa | A | A | 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{n}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide | Human | 11014 | 0.44 | |
| CLK3 | CLK | CMGC | 6rct | A | A | 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{n}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide | Human | 11127 | 0.44 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq7 | B | A | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8605 | 0.41 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5op2 | A | A | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8595 | 0.41 | |
| AURKA (AurA) | Aur | Other | 2bmc | E | | (3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamide | Human | 2069 | 0.43 | |
| AURKA (AurA) | Aur | Other | 2j4z | B | | 4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide | Human | 1990 | 0.42 | |
| CDK8 | CDK | CMGC | 5xqx | A | | n-methyl-4-pyridin-4-yl-1h-pyrrole-2-carboxamide | Human | 8313 | 0.41 | |
| TTK | TTK | Other | 4cv9 | A | | 4-(4-methylpiperazin-1-yl)-n-(2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin-3-yl)benzamide | Human | 4705 | 1.00 | |
| AURKA (AurA) | Aur | Other | 2bmc | F | | (3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamide | Human | 1993 | 0.43 | |
| MAPK14 (p38a) | MAPK | CMGC | 4aac | A | | n-isoxazol-3-yl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxo-quinazolin-3-yl]benzamide | Human | 5048 | 0.42 | |
| AURKA (AurA) | Aur | Other | 2j4z | A | | 4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide | Human | 2053 | 0.42 | |
| PLK1 | PLK | Other | 2owb | A | B | 4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide | Human | 4958 | 0.42 | |
| PLK1 | PLK | Other | 2owb | A | A | 4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamide | Human | 4974 | 0.42 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq7 | A | B | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8594 | 0.41 | |
| TTK | TTK | Other | 4cva | A | | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)-4-(piperidin-1-yl)benzamide | Human | 4713 | 0.81 | |
| CLK1 | CLK | CMGC | 6raa | A | B | 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{n}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide | Human | 11013 | 0.44 | |
| CLK3 | CLK | CMGC | 6rct | B | B | 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{n}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide | Human | 11129 | 0.44 | |
| CLK3 | CLK | CMGC | 6rct | A | B | 4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{n}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide | Human | 11126 | 0.44 | |
| AURKA (AurA) | Aur | Other | 2bmc | B | | (3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamide | Human | 2008 | 0.43 | |
| ITK | Tec | TK | 3qgw | B | A | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | Human | 65 | 0.69 | |
| ITK | Tec | TK | 3qgy | B | A | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 52 | 0.59 | |
| ITK | Tec | TK | 3qgy | B | B | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 66 | 0.59 | |
| ITK | Tec | TK | 3qgw | B | B | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | Human | 14 | 0.69 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jga | A | | n-[5-(4-methylpiperazine-1-carbonyl)[1,1'-biphenyl]-2-yl]-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide | Human | 6886 | 0.40 | |
