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Search results (44 entries covering 18 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
VRK1VRKCK13op5AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48701.00
CAMK2B (CaMK2b)CAMK2CAMK3bhhB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrileHuman15060.76
CAMK2B (CaMK2b)CAMK2CAMK3bhhA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrileHuman15070.76
CDK2CDKCMGC1vywCn-(3-cyclopropyl-1h-pyrazol-5-yl)-2-(2-naphthyl)acetamideHuman41330.41
MAP2K7STE7STE6yg5A[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrileHuman126770.65
STK17B (DRAK2)DAPKCAMK3lm0AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-5-methylpyrimidin-2-yl}amino)phenyl]acetonitrileHuman67960.70
STK17B (DRAK2)DAPKCAMK3lm0AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-5-methylpyrimidin-2-yl}amino)phenyl]acetonitrileHuman67970.70
VRK1VRKCK13op5CA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48861.00
ACVR2A (ACTR2)STKRTKL3socAB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26760.65
SLKSTE20STE2uv2AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18340.65
PAK4STE20STE5bmsAn~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamineHuman13890.50
CDKL3CDKLCMGC3zduA[4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman46770.70
ULK1ULKOther4wnoABn~2~-(4-aminophenyl)-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18760.45
VRK1VRKCK13op5DB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48921.00
VRK2VRKCK18q1zAB2-[4-[[4-[(3-~{tert}-butyl-1~{h}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]ethanenitrileHuman148980.60
VRK2VRKCK18q1zAA2-[4-[[4-[(3-~{tert}-butyl-1~{h}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]ethanenitrileHuman148990.60
SLKSTE20STE2uv2AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18370.65
ACVR2A (ACTR2)STKRTKL3socBA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26770.65
STK26 (MST4)STE20STE3ggfBB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18040.65
ULK1ULKOther4wnoAAn~2~-(4-aminophenyl)-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18810.45
PAK1STE20STE4zy6BAn~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamineHuman1560.50
VRK1VRKCK13op5DA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48781.00
PAK1STE20STE6b16An~4~-(5-cyclopropyl-1h-pyrazol-3-yl)-n~2~-[(1s)-1-(1h-pyrrolo[3,2-b]pyridin-5-yl)ethyl]pyrimidine-2,4-diamineHuman85740.46
VRK1VRKCK13op5CB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48791.00
STK26 (MST4)STE20STE3ggfAB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18080.65
CDKL5CDKLCMGC4bgqAA[4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman14250.70
CDKL5CDKLCMGC4bgqAB[4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman14260.70
PAK1STE20STE4zy6ABn~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamineHuman1730.50
VRK1VRKCK13op5BA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48941.00
AURKA (AurA)AurOther4j8mA1-[4-[[4-[(5-cyclopentyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]ureaHuman20200.53
CDK2CDKCMGC1vywAn-(3-cyclopropyl-1h-pyrazol-5-yl)-2-(2-naphthyl)acetamideHuman39920.41
CAMK2D (CaMK2d)CAMK2CAMK2vn9A[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman21400.65
CAMK2D (CaMK2d)CAMK2CAMK2vn9B[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman21390.65
ACVR2A (ACTR2)STKRTKL3socAA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26750.65
ACVR2A (ACTR2)STKRTKL3socBB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26850.65
PAK1STE20STE6b16Bn~4~-(5-cyclopropyl-1h-pyrazol-3-yl)-n~2~-[(1s)-1-(1h-pyrrolo[3,2-b]pyridin-5-yl)ethyl]pyrimidine-2,4-diamineHuman85750.46
PAK1STE20STE4zy6BBn~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamineHuman1840.50
PAK1STE20STE4zy5An~2~-[(trans-4-aminocyclohexyl)methyl]-n~4~-(3-cyclopropyl-1h-pyrazol-5-yl)pyrimidine-2,4-diamineHuman1550.41
PAK1STE20STE4zy5Bn~2~-[(trans-4-aminocyclohexyl)methyl]-n~4~-(3-cyclopropyl-1h-pyrazol-5-yl)pyrimidine-2,4-diamineHuman1630.41
PAK1STE20STE4zy6AAn~2~-[(7-chloro-1h-benzimidazol-6-yl)methyl]-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamineHuman1380.50
STK26 (MST4)STE20STE3ggfAA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18070.65
STK26 (MST4)STE20STE3ggfBA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18050.65
VRK1VRKCK13op5BB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman49441.00
VRK1VRKCK13op5AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman49421.00
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