KLIFS - the structural kinase database

Search results (17 entries covering 12 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
KDR	VEGFR	TK	3b8q	B		n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5319	0.54
KDR	VEGFR	TK	2rl5	A		n-(4-chlorophenyl)-7-[(6,7-dimethoxyquinolin-4-yl)oxy]-2,3-dihydro-1,4-benzoxazine-4-carboxamide	Human	5348	0.51
KDR	VEGFR	TK	3b8r	A		n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5327	0.43
SLK	STE20	STE	8bem	A	B	tivozanib	Human	14486	0.46
SYK	Syk	TK	3tuc	A		1-benzyl-n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	1195	0.40
ABL1	Abl	TK	8ssn	A		6,7-dimethoxy-n-(4-phenoxyphenyl)quinazolin-4-amine	Human	14878	0.42
KDR	VEGFR	TK	2qu6	B		4-({2-[(4-chloro-3-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-n-methylpyridine-2-carboxamide	Human	5340	0.43
SLK	STE20	STE	8bem	A	A	tivozanib	Human	14487	0.46
KDR	VEGFR	TK	3b8q	A		n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5332	0.54
KDR	VEGFR	TK	4ase	A		tivozanib	Human	5349	0.46
FGFR1	FGFR	TK	4rwl	B		6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methylnaphthalene-1-carboxamide	Human	3596	0.40
KDR	VEGFR	TK	3b8r	B		n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5341	0.43
KDR	VEGFR	TK	2qu6	A		4-({2-[(4-chloro-3-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-n-methylpyridine-2-carboxamide	Human	5316	0.43
ALK	ALK	TK	4fny	A		n-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amine	Human	5367	1.00
MET	Met	TK	3vw8	A		n-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide	Human	2985	0.42
MET	Met	TK	3efk	B		5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3h)-one	Human	2988	0.40
MET	Met	TK	3efk	A		5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3h)-one	Human	3018	0.40