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Search results (58 entries covering 20 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
AURKA (AurA)AurOther3efwA1-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]ureaHuman20100.54
EPHA2 (EphA2)EphTK6q7gAA3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamideHuman119330.43
EPHA2 (EphA2)EphTK6q7gAC3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamideHuman119340.43
EPHA2 (EphA2)EphTK6q7gAB3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamideHuman119380.43
BRAFRAFTKL5vamBAn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman81860.43
MAPK11 (p38b)MAPKCMGC3gp0AAnilotinibHuman27680.40
MAPK11 (p38b)MAPKCMGC3gp0ABnilotinibHuman27640.40
SRPK2SRPKCMGC5myvBB5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman75730.40
BRAFRAFTKL8f7pABn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman147020.40
BRAFRAFTKL8f7pAAn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman147050.40
ABL1AblTK3cs9CAnilotinibHuman10460.40
ERN1 (IRE1)IREOther6w3eBmethyl ~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamateHuman131260.41
KDRVEGFRTK3ewhAn-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1h-benzimidazol-2-amineHuman53510.47
AURKA (AurA)AurOther3efwB1-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]ureaHuman20740.54
ABL1AblTK3cs9AAnilotinibHuman10800.40
ERN1 (IRE1)IREOther6w3aBB~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]but-2-ynamideHuman131190.43
ERN1 (IRE1)IREOther6w3aAA~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]but-2-ynamideHuman131250.43
ERN1 (IRE1)IREOther6w3eAmethyl ~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamateHuman131210.41
SRPK1SRPKCMGC5mxxAB5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman94670.40
ERN1 (IRE1)IREOther6w39BBethyl ~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamateHuman131240.41
ABL1AblTK5mo4ABnilotinibHuman75260.40
ERN1 (IRE1)IREOther6w3aBA~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]but-2-ynamideHuman131180.43
AURKA (AurA)AurOther3o50Bn-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamideHuman20670.47
ABL1AblTK3cs9BBnilotinibHuman11120.40
BRAFRAFTKL5vamBBn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman81870.43
AURKA (AurA)AurOther3o50An-{3-methyl-4-[(3-pyrimidin-4-ylpyridin-2-yl)oxy]phenyl}-3-(trifluoromethyl)benzamideHuman19580.47
BRAFRAFTKL6n0pAAn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman115970.40
BRAFRAFTKL6n0pABn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman115960.40
SRPK2SRPKCMGC5myvAB5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman75750.40
SRPK2SRPKCMGC5myvAA5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman75790.40
SRPK2SRPKCMGC5myvCA5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman75800.40
BRAFRAFTKL5vamABn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman81890.43
ABL1AblTK5mo4AAnilotinibHuman75270.40
BRAFRAFTKL6n0pBBn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman115950.40
ERN1 (IRE1)IREOther6w39AAethyl ~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamateHuman131200.41
SRPK2SRPKCMGC5myvBA5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman75760.40
ERN1 (IRE1)IREOther6w3aAB~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]but-2-ynamideHuman131160.43
SRPK2SRPKCMGC5myvDB5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman75720.40
ERN1 (IRE1)IREOther6w39BAethyl ~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamateHuman131170.41
ABL1AblTK3cs9BAnilotinibHuman10500.40
SRPK2SRPKCMGC5myvCB5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman75710.40
SRPK1SRPKCMGC4wuaAAn-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamideHuman94710.45
ERN1 (IRE1)IREOther6w39ABethyl ~{n}-[6-methyl-5-[3-[2-[[(3~{s})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamateHuman131220.41
ABL1AblTK3cs9CBnilotinibHuman10930.40
ABL1AblTK3cs9DBnilotinibHuman10660.40
ABL1AblTK3cs9ABnilotinibHuman11070.40
MAPK10 (JNK3)MAPKCMGC3da6An-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-1h-benzimidazol-2-amineHuman34760.41
TEK (TIE2)TieTK2p4iB4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-n-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamideHuman55501.00
TEK (TIE2)TieTK2p4iA4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-n-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamideHuman55491.00
TEK (TIE2)TieTK2oscAn-{4-methyl-3-[(3-pyrimidin-4-ylpyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamideHuman55550.40
SRPK1SRPKCMGC4wuaABn-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamideHuman94690.45
SRPK1SRPKCMGC5my8AAsphinx31Human94660.40
SRPK1SRPKCMGC5my8ABsphinx31Human94680.40
ABL1AblTK3cs9DAnilotinibHuman10770.40
SRPK2SRPKCMGC5myvDA5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman75780.40
SRPK1SRPKCMGC5mxxAA5-methyl-~{n}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamideHuman94700.40
BRAFRAFTKL5vamAAn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman81850.43
BRAFRAFTKL6n0pBAn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman115940.40
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