KLIFS - the structural kinase database

Search results (13 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PTK2 (FAK)	FAK	TK	4k9y	A	A	1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea	Human	230	0.43
EPHA3 (EphA3)	Eph	TK	4p5z	A		2-amino-1-[4-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]-1h-pyrrolo[2,3-b]quinoxaline-3-carboxamide	Human	2887	0.42
TGFBR1 (TGFbR1)	STKR	TKL	4x2f	A	B	4-amino-8-(4-aminophenyl)pyrido[2,3-d]pyrimidin-5(8h)-one	Human	6208	0.51
AURKA (AurA)	Aur	Other	6hjk	A		(~{e})-~{n}-[4-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-4-[4-fluoranyl-3-(trifluoromethyl)phenyl]-4-oxidanylidene-but-2-enamide	Human	10411	0.40
NTRK2 (TRKB)	Trk	TK	4at4	A		1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea	Human	3598	0.60
KDR	VEGFR	TK	2oh4	A	A	methyl (5-{4-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-1h-benzimidazol-2-yl)carbamate	Human	5347	0.42
KDR	VEGFR	TK	1ywn	A		n-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-n'-[2-fluoro-5-(trifluoromethyl)phenyl]urea	Human	5314	0.52
PTK2 (FAK)	FAK	TK	4k9y	A	B	1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea	Human	233	0.43
PTK2 (FAK)	FAK	TK	4k9y	A	C	1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea	Human	229	0.43
KDR	VEGFR	TK	2oh4	A	B	methyl (5-{4-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-1h-benzimidazol-2-yl)carbamate	Human	5324	0.42
TGFBR1 (TGFbR1)	STKR	TKL	4x2f	A	A	4-amino-8-(4-aminophenyl)pyrido[2,3-d]pyrimidin-5(8h)-one	Human	6207	0.51
TEK (TIE2)	Tie	TK	4x3j	A		1-[4-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5h)-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea	Human	5552	1.00
MLKL	TKL-Unique	TKL	6o5z	B		1-[2-fluoranyl-5-(trifluoromethyl)phenyl]-3-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]urea	Human	12783	0.44