KLIFS - the structural kinase database

Search results (18 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EPHB4 (EphB4)	Eph	TK	2xvd	A	A	{4-methyl-3-[(1-methylethyl)(2-{[3-(methylsulfonyl)-5-morpholin-4-ylphenyl]amino}pyrimidin-4-yl)amino]phenyl}methanol	Human	363	0.40
ACVR1 (ALK2)	STKR	TKL	7nns	B	A	momelotinib	Human	13465	0.40
RIPK2	RIPK	TKL	5ar8	B		2,6-bis(fluoranyl)-n-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide	Human	6179	1.00
EGFR	EGFR	TK	3lzb	B		n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide	Human	810	0.41
EGFR	EGFR	TK	3lzb	D		n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide	Human	820	0.41
EGFR	EGFR	TK	3lzb	A		n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide	Human	800	0.41
CDK2	CDK	CMGC	2uue	A		4-methyl-5-{(2e)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amine	Human	4515	0.41
EPHB4 (EphB4)	Eph	TK	2xvd	A	B	{4-methyl-3-[(1-methylethyl)(2-{[3-(methylsulfonyl)-5-morpholin-4-ylphenyl]amino}pyrimidin-4-yl)amino]phenyl}methanol	Human	372	0.40
EGFR	EGFR	TK	3lzb	C		n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide	Human	808	0.41
RIPK2	RIPK	TKL	5ar8	A		2,6-bis(fluoranyl)-n-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide	Human	6176	1.00
CDK2	CDK	CMGC	2uue	C		4-methyl-5-{(2e)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amine	Human	4321	0.41
JAK2	JakA	TK	8bxh	A	A	momelotinib	Human	15032	0.40
JAK2	JakA	TK	8bxh	A	B	momelotinib	Human	15045	0.40
ACVR1 (ALK2)	STKR	TKL	7nns	B	B	momelotinib	Human	13464	0.40
MAPK10 (JNK3)	MAPK	CMGC	3kvx	A	A	n-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)aniline	Human	3433	0.41
PAK1	STE20	STE	5kbq	A		[4-methyl-3-[methyl-[2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]pyrimidin-4-yl]amino]phenyl]methanol	Human	7081	0.40
ULK3	ULK	Other	6fdz	U		momelotinib	Human	10390	0.40
MAPK10 (JNK3)	MAPK	CMGC	3kvx	A	B	n-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)aniline	Human	3430	0.41