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Search results (42 entries covering 14 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
VRK1VRKCK13op5AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48700.70
CAMK2B (CaMK2b)CAMK2CAMK3bhhB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrileHuman15060.67
CAMK2B (CaMK2b)CAMK2CAMK3bhhA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrileHuman15070.67
MAP2K7STE7STE6yg5A[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrileHuman126770.68
STK17B (DRAK2)DAPKCAMK3lm0AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-5-methylpyrimidin-2-yl}amino)phenyl]acetonitrileHuman67961.00
STK17B (DRAK2)DAPKCAMK3lm0AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-5-methylpyrimidin-2-yl}amino)phenyl]acetonitrileHuman67971.00
ULK1ULKOther4wnpCBn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18730.40
ULK1ULKOther4wnpABn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18740.40
VRK1VRKCK13op5CA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48860.70
ACVR2A (ACTR2)STKRTKL3socAB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26760.68
SLKSTE20STE2uv2AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18340.68
CDKL3CDKLCMGC3zduA[4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman46770.52
ULK1ULKOther4wnoABn~2~-(4-aminophenyl)-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18760.48
ULK1ULKOther4wnpAAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18780.40
VRK1VRKCK13op5DB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48920.70
VRK2VRKCK18q1zAB2-[4-[[4-[(3-~{tert}-butyl-1~{h}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]ethanenitrileHuman148980.46
VRK2VRKCK18q1zAA2-[4-[[4-[(3-~{tert}-butyl-1~{h}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]ethanenitrileHuman148990.46
SLKSTE20STE2uv2AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18370.68
ACVR2A (ACTR2)STKRTKL3socBA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26770.68
STK26 (MST4)STE20STE3ggfBB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18040.68
ULK1ULKOther4wnpBBn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18790.40
ULK1ULKOther4wnoAAn~2~-(4-aminophenyl)-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18810.48
ULK1ULKOther4wnpBAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18720.40
ULK1ULKOther4wnpDBn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18800.40
VRK1VRKCK13op5DA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48780.70
VRK1VRKCK13op5CB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48790.70
STK26 (MST4)STE20STE3ggfAB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18080.68
CDKL5CDKLCMGC4bgqAB[4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman14260.52
CDKL5CDKLCMGC4bgqAA[4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman14250.52
ULK4ULKOther6u5lABn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman118890.40
VRK1VRKCK13op5BA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48940.70
CAMK2D (CaMK2d)CAMK2CAMK2vn9B[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman21390.68
CAMK2D (CaMK2d)CAMK2CAMK2vn9A[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman21400.68
ACVR2A (ACTR2)STKRTKL3socBB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26850.68
ACVR2A (ACTR2)STKRTKL3socAA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26750.68
STK26 (MST4)STE20STE3ggfBA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18050.68
STK26 (MST4)STE20STE3ggfAA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18070.68
ULK4ULKOther6u5lAAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman118900.40
ULK1ULKOther4wnpDAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18750.40
ULK1ULKOther4wnpCAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18770.40
VRK1VRKCK13op5BB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman49440.70
VRK1VRKCK13op5AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman49420.70
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