KLIFS - the structural kinase database

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
JAK2	JakA	TK	7q7i	A	B	4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol	Human	14088	0.46
MAP4K1 (HPK1)	STE20	STE	8cdw	A	B	~{n}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine	Human	14895	0.40
MAP4K1 (HPK1)	STE20	STE	8cdw	A	A	~{n}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine	Human	14896	0.40
TTK	TTK	Other	5ei6	A		~{n}-(2,4-dimethoxyphenyl)-5-(1-methylpyrazol-4-yl)isoquinolin-3-amine	Human	6558	0.46
TTK	TTK	Other	5ei8	A		~{n}-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine	Human	6557	0.73
TTK	TTK	Other	5ei2	A		~{n}-(2,4-dimethoxyphenyl)-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amine	Human	6559	0.61
JAK2	JakA	TK	7q7i	A	A	4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol	Human	14085	0.46
TTK	TTK	Other	6h3k	A		~{n}8-(2,2-dimethylpropyl)-~{n}2-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-pyrido[3,4-d]pyrimidine-2,8-diamine	Human	10571	0.51
TTK	TTK	Other	5eh0	A		n2-(2-methoxy-4-(1-methyl-1h-pyrazol-4-yl)phenyl)-n8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine	Human	6850	1.00
TTK	TTK	Other	5eho	A		~{n}8-cyclohexyl-~{n}2-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine	Human	7257	0.73