KLIFS - the structural kinase database

Search results (67 entries covering 23 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
JAK2	JakA	TK	4bbf	B		(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide	Human	3717	0.46
CDK2	CDK	CMGC	1oiy	A	B	4-(6-cyclohexylmethoxy-9h-purin-2-ylamino)--benzamide	Human	3945	0.45
JAK2	JakA	TK	4bbf	D		(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide	Human	3663	0.46
JAK2	JakA	TK	4bbe	B		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3727	0.44
CDK2	CDK	CMGC	2iw8	A	B	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4377	0.43
CDK2	CDK	CMGC	5cyi	C	B	6-(cyclohexylmethoxy)-n-[4-(ethylsulfonyl)phenyl]-9h-purin-2-amine	Human	6053	0.43
CDK2	CDK	CMGC	1h1q	C		2-anilino-6-cyclohexylmethoxypurine	Human	4053	0.48
CDK2	CDK	CMGC	4eok	A		o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	3913	0.43
CDK2	CDK	CMGC	1h1r	C	B	6-cyclohexylmethoxy-2-(3'-chloroanilino) purine	Human	4081	0.40
CDK2	CDK	CMGC	1h1r	A	B	6-cyclohexylmethoxy-2-(3'-chloroanilino) purine	Human	4494	0.40
CDK2	CDK	CMGC	1h1s	C		o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4572	0.43
CDK2	CDK	CMGC	4eor	C	B	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4487	0.43
CDK2	CDK	CMGC	4eor	A	B	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	3934	0.43
AURKA (AurA)	Aur	Other	2xne	A		3-chloro-n-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine	Human	7221	0.40
CDK2	CDK	CMGC	4eok	C		o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4385	0.43
CDK2	CDK	CMGC	2iw8	C	A	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4294	0.43
CDK2	CDK	CMGC	2iw9	A	A	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4174	0.43
TTK	TTK	Other	5n7v	A		~{n}6-cyclohexyl-~{n}2-(2-methyl-4-morpholin-4-yl-phenyl)-7~{h}-purine-2,6-diamine	Human	7978	0.58
TTK	TTK	Other	5ljj	A		n~6~-cyclohexyl-n~2~-(4-morpholin-4-ylphenyl)-9h-purine-2,6-diamine	Human	7092	1.00
CDK2	CDK	CMGC	1h1r	A	A	6-cyclohexylmethoxy-2-(3'-chloroanilino) purine	Human	3906	0.40
CDK2	CDK	CMGC	1oiy	C	A	4-(6-cyclohexylmethoxy-9h-purin-2-ylamino)--benzamide	Human	4465	0.45
MAPK1 (Erk2)	MAPK	CMGC	4qp4	A	B	n-cyclohexyl-9h-purin-6-amine	Human	6075	0.43
MAPK1 (Erk2)	MAPK	CMGC	4qp4	B	B	n-cyclohexyl-9h-purin-6-amine	Human	6083	0.43
CDK2	CDK	CMGC	2iw8	C	B	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4350	0.43
JAK2	JakA	TK	4bbe	C		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3649	0.44
CDK2	CDK	CMGC	1h1r	C	A	6-cyclohexylmethoxy-2-(3'-chloroanilino) purine	Human	3920	0.40
JAK2	JakA	TK	4bbf	C		(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide	Human	3644	0.46
CDK2	CDK	CMGC	5cyi	C	A	6-(cyclohexylmethoxy)-n-[4-(ethylsulfonyl)phenyl]-9h-purin-2-amine	Human	6055	0.43
JAK2	JakA	TK	4bbf	A		(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide	Human	3723	0.46
CDK2	CDK	CMGC	2iw8	A	A	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4142	0.43
JAK2	JakA	TK	4bbe	A		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3670	0.44
CDK2	CDK	CMGC	1oi9	C	B	6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine	Human	4036	0.50
MAPK10 (JNK3)	MAPK	CMGC	6emh	B	B	4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amine	Human	10501	0.41
CDK2	CDK	CMGC	4eor	C	A	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4221	0.43
CDK2	CDK	CMGC	5cyi	A	A	6-(cyclohexylmethoxy)-n-[4-(ethylsulfonyl)phenyl]-9h-purin-2-amine	Human	6052	0.43
CDK2	CDK	CMGC	1h1q	A		2-anilino-6-cyclohexylmethoxypurine	Human	4195	0.48
CDK2	CDK	CMGC	1h1s	A		o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4400	0.43
CDK2	CDK	CMGC	2iw9	C	B	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	3858	0.43
CDK2	CDK	CMGC	2c6o	A		o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	6783	0.43
CDK2	CDK	CMGC	5cyi	A	B	6-(cyclohexylmethoxy)-n-[4-(ethylsulfonyl)phenyl]-9h-purin-2-amine	Human	6054	0.43
CDK2	CDK	CMGC	4eor	A	A	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4205	0.43
CDK2	CDK	CMGC	2iw9	C	A	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	4218	0.43
CDK2	CDK	CMGC	1oi9	C	A	6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine	Human	4571	0.50
CDK2	CDK	CMGC	2iw9	A	B	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	3955	0.43
CDK2	CDK	CMGC	1oi9	A	A	6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine	Human	4033	0.50
CDK2	CDK	CMGC	1oi9	A	B	6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine	Human	4492	0.50
JAK2	JakA	TK	8bx6	A	A	cerdulatinib	Human	15033	0.46
JAK2	JakA	TK	4bbe	D		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3726	0.44
JAK2	JakA	TK	8bx6	A	B	cerdulatinib	Human	15042	0.46
MAPK10 (JNK3)	MAPK	CMGC	6emh	B	A	4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amine	Human	10506	0.41
JAK2-b	JakB	TK	6bss	A		o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	10386	0.43
CDK2	CDK	CMGC	1oiy	A	A	4-(6-cyclohexylmethoxy-9h-purin-2-ylamino)--benzamide	Human	4225	0.45
MAPK10 (JNK3)	MAPK	CMGC	6emh	C	B	4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amine	Human	10505	0.41
CDK1 (CDC2)	CDK	CMGC	5lqf	D	A	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	7365	0.43
CDK1 (CDC2)	CDK	CMGC	5lqf	A	A	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	7364	0.43
CDK1 (CDC2)	CDK	CMGC	5lqf	D	B	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	7367	0.43
CDK1 (CDC2)	CDK	CMGC	5lqf	A	B	o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	7366	0.43
CDK2	CDK	CMGC	1oiy	C	B	4-(6-cyclohexylmethoxy-9h-purin-2-ylamino)--benzamide	Human	4245	0.45
NEK2	NEK	Other	5m57	A		o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine	Human	7272	0.43
MAPK10 (JNK3)	MAPK	CMGC	6emh	A	A	4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amine	Human	10508	0.41
MAPK10 (JNK3)	MAPK	CMGC	6emh	D	A	4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amine	Human	10497	0.41
MAPK10 (JNK3)	MAPK	CMGC	6emh	A	B	4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amine	Human	10503	0.41
TTK	TTK	Other	7chm	A		4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	13550	0.41
MAPK1 (Erk2)	MAPK	CMGC	4qp4	B	A	n-cyclohexyl-9h-purin-6-amine	Human	6086	0.43
MAPK1 (Erk2)	MAPK	CMGC	4qp4	A	A	n-cyclohexyl-9h-purin-6-amine	Human	6088	0.43
MAPK10 (JNK3)	MAPK	CMGC	6emh	C	A	4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amine	Human	10507	0.41
MAPK10 (JNK3)	MAPK	CMGC	6emh	D	B	4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amine	Human	10496	0.41