KLIFS - the structural kinase database

Search results (28 entries covering 16 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
SYK	Syk	TK	3fqe	A		2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1155	0.61
SYK	Syk	TK	4rx8	A	A	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)-1,2,4-triazine-6-carboxamide	Human	1158	0.40
SYK	Syk	TK	4rx8	A	B	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)-1,2,4-triazine-6-carboxamide	Human	1168	0.40
CDK1 (CDC2)	CDK	CMGC	6gu4	A		~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine	Human	10777	0.47
CDK2	CDK	CMGC	6guf	A		n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	10770	0.47
CDK2	CDK	CMGC	6guk	A	A	~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine	Human	10773	0.47
SYK	Syk	TK	5tt7	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-5-one	Human	7283	1.00
SYK	Syk	TK	4rx7	A	A	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide	Human	1189	0.47
SYK	Syk	TK	5tr6	A	A	6-{[(1r,2s)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one	Human	7282	0.42
CDK2	CDK	CMGC	6guk	A	B	~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine	Human	10768	0.47
SYK	Syk	TK	4rx7	A	B	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide	Human	1182	0.47
PAK4	STE20	STE	2cdz	A	B	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	1374	0.47
PAK4	STE20	STE	2cdz	A	A	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	1378	0.47
CDK2	CDK	CMGC	6guf	C		n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	10762	0.47
PAK5	STE20	STE	2f57	B	A	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	199	0.47
PAK5	STE20	STE	2f57	B	B	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	201	0.47
SYK	Syk	TK	5tr6	A	B	6-{[(1r,2s)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one	Human	7284	0.42
SYK	Syk	TK	4rx9	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	1194	0.45
SYK	Syk	TK	5tt7	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-5-one	Human	7281	1.00
FES	Fer	TK	6jmf	A		6-{[(1r,2s)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide	Human	11140	0.50
SYK	Syk	TK	5y5t	A		2-[[(1s,2s)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6h-pyrido[4,3-d]pyrimidin-5-one	Human	10028	0.44
JAK2-b	JakB	TK	5ut2	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	8039	0.45
JAK2-b	JakB	TK	5ut2	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	8040	0.45
SYK	Syk	TK	4rx9	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	1190	0.45
SYK	Syk	TK	8x5k	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	15102	0.45
SYK	Syk	TK	8x5k	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	15103	0.45
CSNK1G3 (CK1g3)	CK1	CK1	2izt	A	A	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	2216	0.47
CSNK1G3 (CK1g3)	CK1	CK1	2izt	A	B	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	2215	0.47