KLIFS - the structural kinase database

Search results (17 entries covering 8 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PRKACA (PKACa)	PKA	AGC	5uzk	A	A	2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(1h-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Human	9726	0.74
ROCK1	DMPK	AGC	5uzj	A		n-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide	Human	9706	0.52
ROCK1	DMPK	AGC	5hvu	B		2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	7415	1.00
ROCK1	DMPK	AGC	5kks	B		2-[3-(methylsulfonylamino)phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	8181	0.40
ROCK1	DMPK	AGC	5kkt	A		2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	8182	0.49
ROCK1	DMPK	AGC	3tv7	B		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2703	0.43
ROCK1	DMPK	AGC	4yve	A		2-(3-methoxyphenyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	2693	0.63
ROCK1	DMPK	AGC	3twj	C		1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2689	0.44
ROCK1	DMPK	AGC	5kks	A		2-[3-(methylsulfonylamino)phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	8183	0.40
ROCK1	DMPK	AGC	5hvu	A		2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	7414	1.00
ROCK1	DMPK	AGC	3tv7	C		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2717	0.43
ROCK1	DMPK	AGC	3twj	A		1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2710	0.44
ROCK1	DMPK	AGC	4yve	B		2-(3-methoxyphenyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	2706	0.63
ROCK1	DMPK	AGC	5kkt	B		2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	8184	0.49
ROCK1	DMPK	AGC	3tv7	D		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2725	0.43
ROCK1	DMPK	AGC	5uzj	B		n-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide	Human	9707	0.52
ROCK1	DMPK	AGC	3tv7	A		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2697	0.43