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Search results (66 entries covering 36 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
CDK1 (CDC2)CDKCMGC6gu4A~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamineHuman107770.44
CSNK1G3 (CK1g3)CK1CK12izuAA2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman22181.00
MERTK (MER)AxlTK3bprDB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2820.72
MERTK (MER)AxlTK3bprDA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2790.72
MERTK (MER)AxlTK3bprBB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2750.72
MERTK (MER)AxlTK3bprCB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2760.72
MERTK (MER)AxlTK3bprAA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2780.72
MERTK (MER)AxlTK3bprCA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2840.72
CDK2CDKCMGC1ckpAApurvalanol bHuman40660.75
CDK2CDKCMGC3ddqCAr-roscovitineHuman43640.49
CDK2CDKCMGC5mhqAB(2~{r},3~{s})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-olHuman94080.48
CDK2CDKCMGC3ddpCB(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman67780.43
CDK2CDKCMGC3ddpCA(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman67840.43
CDK2CDKCMGC6gufAn2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamineHuman107700.44
CDK2CDKCMGC3ddqAAr-roscovitineHuman44770.49
CDK2CDKCMGC6gukAA~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamineHuman107730.44
ABL1AblTK6bl8ABpurvalanol bHuman96980.75
CDK2CDKCMGC2a0cXA2-{[(2-{[(1r)-1-(hydroxymethyl)propyl]amino}-9-isopropyl-9h-purin-6-yl)amino]methyl}phenolHuman41570.49
ABL1AblTK6bl8BBpurvalanol bHuman97000.75
CDK2CDKCMGC6gukAB~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamineHuman107680.44
CDK2CDKCMGC3ddqCBr-roscovitineHuman42890.49
RPS6KA1 (RSK3)RSKAGC2z7sA2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman27761.00
PAK4STE20STE2cdzABn2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamineHuman13740.44
PAK4STE20STE2cdzAAn2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamineHuman13780.44
CDK5CDKCMGC1unlAr-roscovitineHuman27850.49
CDK12 (CRK7)CDKCMGC8bulB(2~{r})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149110.48
CDK12 (CRK7)CDKCMGC8bu9Br-roscovitineHuman149140.49
CDK12 (CRK7)CDKCMGC8bupB(2~{r})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149230.51
CDK12 (CRK7)CDKCMGC8buiB(2~{r})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-olHuman149250.53
CDK12 (CRK7)CDKCMGC8bukB(2~{r})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149270.48
CDK12 (CRK7)CDKCMGC8buoB(2~{r})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149340.43
CDK12 (CRK7)CDKCMGC8bujB(2~{r})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149330.49
CDK12 (CRK7)CDKCMGC8butB2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149360.43
CDK2CDKCMGC6gufCn2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamineHuman107620.44
PAK5STE20STE2f57BAn2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamineHuman1990.44
PAK5STE20STE2f57BBn2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamineHuman2010.44
CDK2CDKCMGC5mhqAA(2~{r},3~{s})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-olHuman94090.48
MERTK (MER)AxlTK3bprBA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2810.72
SRPK2SRPKCMGC2x7gApurvalanol bHuman14090.75
MERTK (MER)AxlTK3bprAB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2630.72
CDK2CDKCMGC2a4lAr-roscovitineHuman42380.49
CDK2CDKCMGC3ddpAB(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman67800.43
CDK9CDKCMGC3lq5A(2s)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman22530.43
ABL1AblTK6bl8BApurvalanol bHuman97010.75
ABL1AblTK6bl8AApurvalanol bHuman96990.75
CDK2CDKCMGC2a0cXB2-{[(2-{[(1r)-1-(hydroxymethyl)propyl]amino}-9-isopropyl-9h-purin-6-yl)amino]methyl}phenolHuman38680.49
CDK2CDKCMGC1ckpABpurvalanol bHuman42140.75
CDK2CDKCMGC3ddpAA(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman67810.43
SRCSrcTK1yomB2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman9871.00
CDK2CDKCMGC8fp0ABr-roscovitineHuman147560.49
CDK2CDKCMGC8fp0AAr-roscovitineHuman147580.49
CDK2CDKCMGC3ddqABr-roscovitineHuman42690.49
CSNK1G1 (CK1g1)CK1CK12cmwAB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman55660.72
CSNK1G1 (CK1g1)CK1CK12cmwAA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman55670.72
SRCSrcTK1yomA2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman9731.00
CDK12 (CRK7)CDKCMGC8buhB6-[[[2-[[(2~{r})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{h}-pyridin-2-oneHuman149220.40
CDK12 (CRK7)CDKCMGC8bunB(2~{r})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149160.46
CDK12 (CRK7)CDKCMGC8bumB(2r)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149240.47
CDK12 (CRK7)CDKCMGC8buqB(2~{r})-2-[[6-[[1-(3-chlorophenyl)pyrazol-3-yl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149170.53
CDK12 (CRK7)CDKCMGC6td3E(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman123690.43
CDK12 (CRK7)CDKCMGC6td3H(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman123700.43
CDK12 (CRK7)CDKCMGC6td3B(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman123710.43
CSNK1G3 (CK1g3)CK1CK12izuAB2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman22251.00
CSNK1G3 (CK1g3)CK1CK12iztAAn2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamineHuman22160.44
CSNK1G3 (CK1g3)CK1CK12iztABn2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamineHuman22150.44
CDK6CDKCMGC2f2cB(2s)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman27950.82
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