KLIFS - the structural kinase database

Search results (13 entries covering 8 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
SYK	Syk	TK	4pv0	A		4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid	Human	1161	1.00
BTK	Tec	TK	4ot5	A		4-tert-butyl-n-{3-[8-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]phenyl}benzamide	Human	2913	0.62
SYK	Syk	TK	4fyo	A	A	4-{[(3s)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid	Human	1180	0.40
FGFR1	FGFR	TK	4uwc	A	B	3,4-dimethoxy-n-(5-phenyl-1h-pyrazol-3-yl)benzamide	Human	6017	0.43
SYK	Syk	TK	4fyo	A	B	4-{[(3s)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid	Human	1205	0.40
SYK	Syk	TK	5c26	A		3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzamide	Human	6131	0.79
SYK	Syk	TK	4puz	A		6-(1h-indazol-6-yl)-n-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine	Human	1163	0.40
SYK	Syk	TK	4puz	B		6-(1h-indazol-6-yl)-n-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine	Human	1153	0.40
SYK	Syk	TK	5c27	A		3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}-n-[4-(methylcarbamoyl)phenyl]benzamide	Human	6132	0.86
FGFR1	FGFR	TK	4uwc	B	B	3,4-dimethoxy-n-(5-phenyl-1h-pyrazol-3-yl)benzamide	Human	6016	0.43
FGFR1	FGFR	TK	4uwc	B	A	3,4-dimethoxy-n-(5-phenyl-1h-pyrazol-3-yl)benzamide	Human	6021	0.43
FGFR1	FGFR	TK	4uwc	A	A	3,4-dimethoxy-n-(5-phenyl-1h-pyrazol-3-yl)benzamide	Human	6019	0.43
BTK	Tec	TK	4ot6	A		4-(methylsulfonyl)-n-[3-(8-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}imidazo[1,2-a]pyrazin-6-yl)phenyl]benzamide	Human	2931	0.55