| JAK3 | JakA | TK | 4i6q | A | | n-[(1s)-1-cyclopropylethyl]-2-phenoxy-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 432 | 0.43 | |
| SYK | Syk | TK | 4i0r | A | B | n-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1175 | 1.00 | |
| JAK3 | JakA | TK | 4hvh | A | | 2-cyclopropyl-n-[(2r)-3-hydroxy-3-methylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 441 | 0.48 | |
| SYK | Syk | TK | 4i0s | A | A | 2-(6-chloro-1-methyl-1h-indazol-3-yl)-n-(propan-2-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1157 | 0.60 | |
| SYK | Syk | TK | 4i0t | A | B | n-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1164 | 0.42 | |
| SYK | Syk | TK | 4i0s | A | B | 2-(6-chloro-1-methyl-1h-indazol-3-yl)-n-(propan-2-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1166 | 0.60 | |
| SYK | Syk | TK | 4i0t | A | A | n-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1198 | 0.42 | |
| SYK | Syk | TK | 4i0r | A | A | n-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1192 | 1.00 | |
| JAK3 | JakA | TK | 3zc6 | A | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 461 | 0.44 | |
| JAK3 | JakA | TK | 4hvi | A | | 2-cyclopropyl-n-[(2r)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 438 | 0.48 | |
| JAK3 | JakA | TK | 3zc6 | B | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 449 | 0.44 | |
| JAK3 | JakA | TK | 3zc6 | B | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 447 | 0.44 | |
| JAK3 | JakA | TK | 3zc6 | C | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 445 | 0.44 | |
| JAK3 | JakA | TK | 3zc6 | A | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 442 | 0.44 | |
| JAK3 | JakA | TK | 3zc6 | D | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 459 | 0.44 | |
| JAK3 | JakA | TK | 4hvg | A | | 2-cyclopropyl-n-[(2s)-3-hydroxy-3-methylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 450 | 0.48 | |
| JAK3 | JakA | TK | 3zc6 | C | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 433 | 0.44 | |
| JAK3 | JakA | TK | 3zc6 | D | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 446 | 0.44 | |
| JAK3 | JakA | TK | 4hvd | A | | 2-cyclopropyl-n-[(2s)-3,3-dimethylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 431 | 0.49 | |
| NEK2 | NEK | Other | 2xkd | A | A | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]benzoic acid | Human | 330 | 0.40 | |
| NEK2 | NEK | Other | 2xkc | A | B | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid | Human | 307 | 0.40 | |
| NEK2 | NEK | Other | 2xkc | A | A | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid | Human | 321 | 0.40 | |
| NEK2 | NEK | Other | 2xkf | A | B | 1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid | Human | 311 | 0.40 | |
| NEK2 | NEK | Other | 2xk4 | A | B | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-ethoxybenzoic acid | Human | 316 | 0.42 | |
| NEK2 | NEK | Other | 2xkf | A | A | 1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid | Human | 315 | 0.40 | |
| NEK2 | NEK | Other | 2xk4 | A | C | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-ethoxybenzoic acid | Human | 304 | 0.42 | |
| NEK2 | NEK | Other | 2xk4 | A | A | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-ethoxybenzoic acid | Human | 314 | 0.42 | |
| NEK2 | NEK | Other | 2xkd | A | B | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]benzoic acid | Human | 298 | 0.40 | |
| NEK2 | NEK | Other | 2xk8 | A | | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methoxybenzoic acid | Human | 300 | 0.42 | |
