| SYK | Syk | TK | 3tub | A | | 1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1r,2s)-2-phenylcyclopropyl]urea | Human | 1179 | 1.00 | |
| KDR | VEGFR | TK | 6xvk | A | | ~{n}-(4,4-dimethyl-2-prop-1-ynyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12273 | 0.40 | |
| KDR | VEGFR | TK | 3b8q | B | | n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | Human | 5319 | 0.45 | |
| KDR | VEGFR | TK | 2rl5 | A | | n-(4-chlorophenyl)-7-[(6,7-dimethoxyquinolin-4-yl)oxy]-2,3-dihydro-1,4-benzoxazine-4-carboxamide | Human | 5348 | 0.43 | |
| KDR | VEGFR | TK | 3b8r | A | | n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | Human | 5327 | 0.53 | |
| SLK | STE20 | STE | 8bem | A | B | tivozanib | Human | 14486 | 0.42 | |
| SYK | Syk | TK | 3tuc | A | | 1-benzyl-n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 1195 | 0.58 | |
| KIT | PDGFR | TK | 6xva | B | | ~{n}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide | Human | 12281 | 0.40 | |
| KIT | PDGFR | TK | 6xva | A | | ~{n}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide | Human | 12284 | 0.40 | |
| KDR | VEGFR | TK | 3wzd | A | B | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | Human | 5350 | 0.50 | |
| FGFR1 | FGFR | TK | 5zv2 | B | | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | Human | 10054 | 0.50 | |
| KIT | PDGFR | TK | 6xvb | B | | ~{n}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12280 | 0.40 | |
| SLK | STE20 | STE | 8bem | A | A | tivozanib | Human | 14487 | 0.42 | |
| FGFR1 | FGFR | TK | 5zv2 | A | | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | Human | 10055 | 0.50 | |
| EIF2AK3 (PEK) | PEK | Other | 4x7h | A | B | n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 7240 | 0.58 | |
| KDR | VEGFR | TK | 3b8q | A | | n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | Human | 5332 | 0.45 | |
| KDR | VEGFR | TK | 4ase | A | | tivozanib | Human | 5349 | 0.42 | |
| FGFR1 | FGFR | TK | 4rwl | B | | 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methylnaphthalene-1-carboxamide | Human | 3596 | 0.45 | |
| KDR | VEGFR | TK | 3b8r | B | | n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | Human | 5341 | 0.53 | |
| KDR | VEGFR | TK | 3u6j | A | | n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 5318 | 0.41 | |
| KDR | VEGFR | TK | 3wzd | A | A | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | Human | 5325 | 0.50 | |
| MET | Met | TK | 3u6h | A | B | n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 2965 | 0.41 | |
| EIF2AK3 (PEK) | PEK | Other | 4x7h | A | A | n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 7247 | 0.58 | |
| KIT | PDGFR | TK | 6xvb | A | | ~{n}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12279 | 0.40 | |
| MET | Met | TK | 3u6h | A | A | n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 2996 | 0.41 | |
| MET | Met | TK | 3vw8 | A | | n-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide | Human | 2985 | 0.50 | |
