KLIFS - the structural kinase database

Search results (30 entries covering 15 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PRKACA (PKACa)	PKA	AGC	5uzk	A	A	2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(1h-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide	Human	9726	0.46
ROCK1	DMPK	AGC	5uzj	A		n-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide	Human	9706	1.00
PRKACA (PKACa)	PKA	AGC	3poo	A	B	n'-[(e)-(2,4-dihydroxy-6-methylphenyl)methylidene]-2-(3-methoxyphenyl)acetohydrazide	Human	5285	0.40
PRKACA (PKACa)	PKA	AGC	3poo	A	A	n'-[(e)-(2,4-dihydroxy-6-methylphenyl)methylidene]-2-(3-methoxyphenyl)acetohydrazide	Human	5300	0.40
BTK	Tec	TK	6n9p	A	A	n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide	Human	10886	0.41
PRKACA (PKACa)	PKA	AGC	3ovv	A	A	n'-[(1e)-(4-hydroxyphenyl)methylidene]-2-(3-methoxyphenyl)acetohydrazide	Human	5266	0.41
BTK	Tec	TK	6n9p	A	C	n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide	Human	10888	0.41
DYRK1A	DYRK	CMGC	7aj2	A	B	4-(4-methoxyphenyl)pyridin-2-amine	Human	13592	0.42
ROCK1	DMPK	AGC	5hvu	B		2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	7415	0.52
Pik3c2a	PIP	Atypical	7z74	A	B	~{n}-[4-(3-hydroxyphenyl)-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide	Mouse	14357	0.40
Pik3c2a	PIP	Atypical	7z75	A		~{n}-[4-[3-(methylsulfonylamino)phenyl]-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide	Mouse	14359	0.40
ROCK1	DMPK	AGC	5kks	B		2-[3-(methylsulfonylamino)phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	8181	0.49
ROCK1	DMPK	AGC	5kkt	A		2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	8182	0.47
ROCK1	DMPK	AGC	3tv7	B		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2703	0.49
MAP2K6	STE7	STE	8pm3	A		~{n}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide	Human	14994	0.49
ROCK1	DMPK	AGC	4yve	A		2-(3-methoxyphenyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	2693	0.77
DYRK1A	DYRK	CMGC	7aj2	A	A	4-(4-methoxyphenyl)pyridin-2-amine	Human	13609	0.42
Pik3c2a	PIP	Atypical	7z74	A	A	~{n}-[4-(3-hydroxyphenyl)-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide	Mouse	14360	0.40
PRKACA (PKACa)	PKA	AGC	3ovv	A	B	n'-[(1e)-(4-hydroxyphenyl)methylidene]-2-(3-methoxyphenyl)acetohydrazide	Human	5269	0.41
ROCK1	DMPK	AGC	3twj	C		1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2689	0.42
BTK	Tec	TK	6n9p	A	B	n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide	Human	10887	0.41
ROCK1	DMPK	AGC	5kks	A		2-[3-(methylsulfonylamino)phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	8183	0.49
ROCK1	DMPK	AGC	5hvu	A		2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	7414	0.52
ROCK1	DMPK	AGC	3tv7	C		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2717	0.49
ROCK1	DMPK	AGC	3twj	A		1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2710	0.42
ROCK1	DMPK	AGC	4yve	B		2-(3-methoxyphenyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide	Human	2706	0.77
ROCK1	DMPK	AGC	5kkt	B		2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide	Human	8184	0.47
ROCK1	DMPK	AGC	3tv7	D		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2725	0.49
ROCK1	DMPK	AGC	5uzj	B		n-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide	Human	9707	1.00
ROCK1	DMPK	AGC	3tv7	A		1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Human	2697	0.49