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Search results (91 entries covering 52 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
PTK2 (FAK)FAKTK4k9yAA1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman2300.45
Mapk14 (p38a)MAPKCMGC6y6vAA5-azanyl-~{n}-[[4-[[5-~{tert}-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamideMouse120660.41
EPHA3 (EphA3)EphTK4twnAB1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman28650.46
Mapk14 (p38a)MAPKCMGC6y6vAB5-azanyl-~{n}-[[4-[[5-~{tert}-butyl-2-(4-methylphenyl)pyrazol-3-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamideMouse120670.41
CDK8CDKCMGC4f7jAA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl)ureaHuman38420.52
CDK16 (PCTAIRE1)CDKCMGC5g6vB4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman72740.40
STK10 (LOK)STE20STE6gttAA1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman100260.46
MAPK14 (p38a)MAPKCMGC3hv5AA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}ureaHuman52030.43
ABL1AblTK3qrjBA4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman11010.40
ABL1AblTK3qrjAA4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman10850.40
EPHA3 (EphA3)EphTK4twnAA1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman28460.46
MAPK11 (p38b)MAPKCMGC8ygwA1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman152340.46
BRAFRAFTKL4jvgC1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman30500.46
ABL1AblTK3qriBA4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman11030.40
MAPK14 (p38a)MAPKCMGC3pg3AB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{4-[2-(pyridin-3-ylmethoxy)ethyl]-1,3-thiazol-2-yl}ureaHuman50960.56
MAPK14 (p38a)MAPKCMGC3hv5AB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}ureaHuman52630.43
MAPK14 (p38a)MAPKCMGC3gcuBB1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman51260.45
MAPK14 (p38a)MAPKCMGC1kv2A1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman52550.46
MAPK14 (p38a)MAPKCMGC3hv5BA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}ureaHuman50850.43
MAPK14 (p38a)MAPKCMGC3nnwAB2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1h-pyrazol-1-yl)phenyl]acetamideHuman51380.41
MAPK14 (p38a)MAPKCMGC3lffAB(4-{3-tert-butyl-5-[(1,3-thiazol-2-ylcarbamoyl)amino]-1h-pyrazol-1-yl}phenyl)acetic acidHuman51200.44
MAPK14 (p38a)MAPKCMGC3lfbAA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)ureaHuman49980.52
MAPK14 (p38a)MAPKCMGC3nnvAA1-{3-tert-butyl-1-[4-(hydroxymethyl)phenyl]-1h-pyrazol-5-yl}-3-naphthalen-1-ylureaHuman50370.44
ABL1AblTK3qrkA(3s)-6-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]amino}-1h-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acidHuman10560.40
ABL1AblTK3qriBB4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman10760.40
CDK16 (PCTAIRE1)CDKCMGC5g6vA4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman72730.40
MAPK14 (p38a)MAPKCMGC3lfcA(4-{5-[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}carbamoyl)amino]-3-tert-butyl-1h-pyrazol-1-yl}phenyl)acetic acidHuman51600.41
MAPK14 (p38a)MAPKCMGC3hv7A1-[1-(3-aminophenyl)-3-tert-butyl-1h-pyrazol-5-yl]-3-naphthalen-1-ylureaHuman52230.42
MAPK14 (p38a)MAPKCMGC3lfeA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{4-[2-(pyridin-4-ylmethoxy)ethyl]-1,3-thiazol-2-yl}ureaHuman51730.49
MAPK14 (p38a)MAPKCMGC3nnxA2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1h-pyrazol-1-yl)phenyl]acetamideHuman50020.41
MAPK14 (p38a)MAPKCMGC3pg3AA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{4-[2-(pyridin-3-ylmethoxy)ethyl]-1,3-thiazol-2-yl}ureaHuman51220.56
CDK8CDKCMGC4f70A1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]ureaHuman38520.49
MAPK14 (p38a)MAPKCMGC2bajA1-(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)-3-(2,3-dichlorophenyl)ureaHuman51760.45
CDK8CDKCMGC4f6wAn-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-4-[2-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine-1-carboxamideHuman38450.48
MAPK14 (p38a)MAPKCMGC1wbnAn-(3-tert-butyl-1h-pyrazol-5-yl)-n'-{4-chloro-3-[(pyridin-3-yloxy)methyl]phenyl}ureaHuman52570.56
MAPK14 (p38a)MAPKCMGC3hv6A1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]ureaHuman51010.49
MAPK14 (p38a)MAPKCMGC3gcuBA1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman51750.45
BRAFRAFTKL4jvgA1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman31340.46
BRAFRAFTKL4jvgB1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman30850.46
MAPK14 (p38a)MAPKCMGC3uvrAA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(5-oxo-6,7,8,9-tetrahydro-5h-benzo[7]annulen-2-yl)amino]phenyl}ureaHuman68800.44
MAPK14 (p38a)MAPKCMGC3hv4A1-{3-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman51210.46
MAPK14 (p38a)MAPKCMGC3nnwAA2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1h-pyrazol-1-yl)phenyl]acetamideHuman51390.41
MAPK14 (p38a)MAPKCMGC3hv3AB1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1h-pyrazol-5-yl]ureaHuman52320.41
MAPK14 (p38a)MAPKCMGC3lffAA(4-{3-tert-butyl-5-[(1,3-thiazol-2-ylcarbamoyl)amino]-1h-pyrazol-1-yl}phenyl)acetic acidHuman51400.44
MAPK14 (p38a)MAPKCMGC1w82An-[(3z)-5-tert-butyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-ylidene]-n'-(4-chlorophenyl)ureaHuman51650.45
MAPK14 (p38a)MAPKCMGC3uvrAB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(5-oxo-6,7,8,9-tetrahydro-5h-benzo[7]annulen-2-yl)amino]phenyl}ureaHuman68790.44
CDK8CDKCMGC4f7jAB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl)ureaHuman38430.52
MAPK14 (p38a)MAPKCMGC3lfdA1-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman51020.48
CDK8CDKCMGC4f6uAA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]ureaHuman38490.45
CDK8CDKCMGC4f7nA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5-hydroxypentyl)ureaHuman38470.50
BRAFRAFTKL4jvgD1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman30590.46
MAPK14 (p38a)MAPKCMGC5n66A1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman85240.46
MAPK14 (p38a)MAPKCMGC3gcuAB1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman51620.45
PTK2B (PYK2)FAKTK4h1jA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1h-pyrazol-5-yl]ureaHuman910.59
PTK2B (PYK2)FAKTK3fzsA1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman940.46
MAPK14 (p38a)MAPKCMGC3lfbAB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)ureaHuman50010.52
PTK2B (PYK2)FAKTK3fztA1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3h-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1h-pyrazol-5-yl}ureaHuman861.00
MAPK14 (p38a)MAPKCMGC3nnvAB1-{3-tert-butyl-1-[4-(hydroxymethyl)phenyl]-1h-pyrazol-5-yl}-3-naphthalen-1-ylureaHuman50460.44
CDK8CDKCMGC4f6sA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman38480.52
MAPK9 (JNK2)MAPKCMGC3npcA1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman12350.46
MAPK9 (JNK2)MAPKCMGC3npcB1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman12370.46
ABL1AblTK3qriAB4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman10470.40
CDK8CDKCMGC4f7lAtert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)propyl]carbamateHuman38400.50
CDK8CDKCMGC4f6uAB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]ureaHuman38440.45
MAPK14 (p38a)MAPKCMGC6qdzAB1-[5-~{tert}-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[(1~{s},4~{s})-4-[(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy]-1,2,3,4-tetrahydronaphthalen-1-yl]ureaHuman119580.40
MAPK14 (p38a)MAPKCMGC6qdzAA1-[5-~{tert}-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[(1~{s},4~{s})-4-[(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy]-1,2,3,4-tetrahydronaphthalen-1-yl]ureaHuman119560.40
MAPK14 (p38a)MAPKCMGC6qe1A1-[5-~{tert}-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[(1~{s},4~{r})-4-[(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy]-1,2,3,4-tetrahydronaphthalen-1-yl]ureaHuman119570.40
ABL1AblTK3qrjAB4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman10990.40
PTK2 (FAK)FAKTK4k9yAB1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman2330.45
PTK2 (FAK)FAKTK4kaoB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]ureaHuman2530.62
PTK2 (FAK)FAKTK4kaoA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]ureaHuman2480.62
PTK2 (FAK)FAKTK4k9yAC1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman2290.45
ABL1AblTK3qrjBB4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman10700.40
MAPK14 (p38a)MAPKCMGC3hv3AA1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1h-pyrazol-5-yl]ureaHuman50120.41
PTK2B (PYK2)FAKTK4h1mA7-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)-n-(propan-2-yl)-1h-indole-2-carboxamideHuman890.47
MAPK14 (p38a)MAPKCMGC3gcuAA1-{3-[(6-aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman50320.45
TEK (TIE2)TieTK6mweBA4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman107120.40
TEK (TIE2)TieTK6mweBB4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman107130.40
TEK (TIE2)TieTK6mweAA4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman107100.40
TEK (TIE2)TieTK6mweAB4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman107110.40
ABL1AblTK3qriAA4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman10510.40
TTKTTKOther5ehlA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman72560.52
MAP3K7 (TAK1)MLKTKL2yiyA(1e)-1-[5-tert-butyl-2-(3-fluorophenyl)-1h-pyrazol-3-ylidene]-3-(4-pyridin-3-yloxyphenyl)ureaHuman18900.51
MAPK14 (p38a)MAPKCMGC3hv4B1-{3-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman50640.46
MAPK14 (p38a)MAPKCMGC3hv5BB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}ureaHuman51370.43
STK10 (LOK)STE20STE6gttAB1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-ureaHuman100250.46
NTRK1 (TRKA)TrkTK6pl3AA2-[(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)amino]-2-oxoethyl 4-(1h-tetrazol-1-yl)benzoateHuman115990.42
NTRK1 (TRKA)TrkTK6pl3AB2-[(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)amino]-2-oxoethyl 4-(1h-tetrazol-1-yl)benzoateHuman116000.42
NTRK1 (TRKA)TrkTK6pl2An-(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)-2-{[1-(4-hydroxyphenyl)-1h-tetrazol-5-yl]sulfanyl}acetamideHuman115980.42
PRPF4B (PRP4)DYRKCMGC6cnhAB4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman97750.40
PRPF4B (PRP4)DYRKCMGC6cnhAA4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamideHuman97760.40
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