| VRK1 | VRK | CK1 | 3op5 | A | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4870 | 0.65 | |
| CAMK2B (CaMK2b) | CAMK2 | CAMK | 3bhh | B | | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 1506 | 0.65 | |
| CAMK2B (CaMK2b) | CAMK2 | CAMK | 3bhh | A | | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 1507 | 0.65 | |
| CDK2 | CDK | CMGC | 1vyw | C | | n-(3-cyclopropyl-1h-pyrazol-5-yl)-2-(2-naphthyl)acetamide | Human | 4133 | 0.43 | |
| MAP2K7 | STE7 | STE | 6yg5 | A | | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile | Human | 12677 | 1.00 | |
| STK17B (DRAK2) | DAPK | CAMK | 3lm0 | A | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-5-methylpyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 6796 | 0.68 | |
| STK17B (DRAK2) | DAPK | CAMK | 3lm0 | A | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-5-methylpyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 6797 | 0.68 | |
| ULK1 | ULK | Other | 4wnp | A | B | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1874 | 0.62 | |
| ULK1 | ULK | Other | 4wnp | C | B | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1873 | 0.62 | |
| VRK1 | VRK | CK1 | 3op5 | C | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4886 | 0.65 | |
| ACVR2A (ACTR2) | STKR | TKL | 3soc | A | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2676 | 1.00 | |
| SLK | STE20 | STE | 2uv2 | A | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 1834 | 1.00 | |
| ULK1 | ULK | Other | 4wno | A | B | n~2~-(4-aminophenyl)-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1876 | 0.75 | |
| ULK1 | ULK | Other | 4wnp | A | A | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1878 | 0.62 | |
| CDKL3 | CDKL | CMGC | 3zdu | A | | [4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4677 | 0.48 | |
| VRK1 | VRK | CK1 | 3op5 | D | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4892 | 0.65 | |
| VRK2 | VRK | CK1 | 8q1z | A | B | 2-[4-[[4-[(3-~{tert}-butyl-1~{h}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]ethanenitrile | Human | 14898 | 0.41 | |
| VRK2 | VRK | CK1 | 8q1z | A | A | 2-[4-[[4-[(3-~{tert}-butyl-1~{h}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]ethanenitrile | Human | 14899 | 0.41 | |
| SLK | STE20 | STE | 2uv2 | A | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 1837 | 1.00 | |
| ACVR2A (ACTR2) | STKR | TKL | 3soc | B | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2677 | 1.00 | |
| STK26 (MST4) | STE20 | STE | 3ggf | B | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 1804 | 1.00 | |
| ULK1 | ULK | Other | 4wnp | B | B | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1879 | 0.62 | |
| ULK1 | ULK | Other | 4wno | A | A | n~2~-(4-aminophenyl)-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1881 | 0.75 | |
| ULK1 | ULK | Other | 4wnp | D | B | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1880 | 0.62 | |
| ULK1 | ULK | Other | 4wnp | B | A | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1872 | 0.62 | |
| VRK1 | VRK | CK1 | 3op5 | D | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4878 | 0.65 | |
| CDK2 | CDK | CMGC | 1vyz | A | | n-(5-cyclopropyl-1h-pyrazol-3-yl)benzamide | Human | 4325 | 0.40 | |
| VRK1 | VRK | CK1 | 3op5 | C | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4879 | 0.65 | |
| STK26 (MST4) | STE20 | STE | 3ggf | A | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 1808 | 1.00 | |
| CDKL5 | CDKL | CMGC | 4bgq | A | A | [4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 1425 | 0.48 | |
| CDKL5 | CDKL | CMGC | 4bgq | A | B | [4-({4-[(3-cyclopentyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 1426 | 0.48 | |
| CAMK1D (CaMK1d) | CAMK1 | CAMK | 2jc6 | A | B | n-(5-methyl-1h-pyrazol-3-yl)-2-phenylquinazolin-4-amine | Human | 4830 | 0.44 | |
| ULK4 | ULK | Other | 6u5l | A | B | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 11889 | 0.62 | |
| VRK1 | VRK | CK1 | 3op5 | B | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4894 | 0.65 | |
| CDK2 | CDK | CMGC | 1vyw | A | | n-(3-cyclopropyl-1h-pyrazol-5-yl)-2-(2-naphthyl)acetamide | Human | 3992 | 0.43 | |
| CAMK2D (CaMK2d) | CAMK2 | CAMK | 2vn9 | B | | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2139 | 1.00 | |
| CAMK2D (CaMK2d) | CAMK2 | CAMK | 2vn9 | A | | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2140 | 1.00 | |
| ACVR2A (ACTR2) | STKR | TKL | 3soc | B | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2685 | 1.00 | |
| ACVR2A (ACTR2) | STKR | TKL | 3soc | A | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2675 | 1.00 | |
| CAMK1D (CaMK1d) | CAMK1 | CAMK | 2jc6 | C | B | n-(5-methyl-1h-pyrazol-3-yl)-2-phenylquinazolin-4-amine | Human | 4831 | 0.44 | |
| CAMK1D (CaMK1d) | CAMK1 | CAMK | 2jc6 | C | A | n-(5-methyl-1h-pyrazol-3-yl)-2-phenylquinazolin-4-amine | Human | 4832 | 0.44 | |
| CAMK1D (CaMK1d) | CAMK1 | CAMK | 2jc6 | A | A | n-(5-methyl-1h-pyrazol-3-yl)-2-phenylquinazolin-4-amine | Human | 4829 | 0.44 | |
| STK26 (MST4) | STE20 | STE | 3ggf | B | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 1805 | 1.00 | |
| STK26 (MST4) | STE20 | STE | 3ggf | A | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 1807 | 1.00 | |
| ULK4 | ULK | Other | 6u5l | A | A | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 11890 | 0.62 | |
| ULK1 | ULK | Other | 4wnp | D | A | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1875 | 0.62 | |
| ULK1 | ULK | Other | 4wnp | C | A | n~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamine | Human | 1877 | 0.62 | |
| VRK1 | VRK | CK1 | 3op5 | B | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4944 | 0.65 | |
| VRK1 | VRK | CK1 | 3op5 | A | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | Human | 4942 | 0.65 | |
