KLIFS - the structural kinase database

Search results (16 entries covering 13 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PIK3CG (p110g)	PIK	Atypical	3ene	A		1-methyl-3-naphthalen-2-yl-1h-pyrazolo[3,4-d]pyrimidin-4-amine	Human	9188	0.47
PIK3CG (p110g)	PIK	Atypical	2v4l	A		3-[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]phenol	Human	9237	0.43
BMX	Tec	TK	3sxs	A		1-tert-butyl-3-(4-chloro-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	3483	0.46
LCK	Src	TK	1qpe	A		1-tert-butyl-3-(4-chloro-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	2271	0.46
EGFR	EGFR	TK	8tjl	A		1-{3-[(4-amino-1-tert-butyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]azetidin-1-yl}propan-1-one	Human	15237	0.41
RET	Ret	TK	5fm2	A		1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	7328	1.00
HCK	Src	TK	1qcf	A		1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	2641	1.00
HCK	Src	TK	3vs6	B		tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate	Human	2656	0.40
HCK	Src	TK	3vs6	A		tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate	Human	2664	0.40
SRC	Src	TK	4k11	A	A	1-tert-butyl-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine	Human	983	0.57
SRC	Src	TK	4k11	A	B	1-tert-butyl-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine	Human	977	0.57
PIK3CA (p110a)	PIK	Atypical	6gvf	A	B	5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	11658	0.43
PIK3CA (p110a)	PIK	Atypical	6gvf	A	A	5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	11659	0.43
RET	Ret	TK	2ivv	A		1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	3373	1.00
RET	Ret	TK	5fm3	A		1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Human	7327	1.00
Lyn (LYN)	Src	TK	2zv9	A		1-tert-butyl-3-(4-chloro-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine	Mouse	5773	0.46