3FQS - chain A (model A) | Spleen tyrosine kinase
Structure information
| PDB: | 3FQS |
| PubMed: | 19220318 |
| Release date: | 2009-03-10 |
| Resolution: | 2.1 Å |
| Kinase: | SYK |
| Family: | Syk |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.9Å) |
| ASP rotation (xDFG.81) : | 350° |
| PHE rotation (xDFG.82) : | 15° |
| Activation loop position: | -3.4Å |
| αC-helix position: | 18.1Å |
| G-rich loop angle: | 63.6° |
| G-rich loop distance: | 19.5Å |
| G-rich loop rotation: | 58.8° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I4
H-bond protein
I5
H-bond protein
I10
H-bond ligand
I11
H-bond ligand
Binding pocket sequence
| Uniprot | KELGSGNFGTVKKVAVKILELLAEANVMQQLDPYIVRMIGIMLVMEMAELGPLNKYLQQYLEESNFVHRDLAARNVLLISDFGLS |
| Structure: | KELGSGNFGTVKKVAVKILELLAEANVMQQLDPYIVRMIGIMLVMEMAELGPLNKYLQQYLEESNFVHRDLAARNVLLISDFGLS |
Modified residues
No modified residues identified.
Orthosteric ligand
Ligand HET-code: 585
Ligand Name: 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
| Main pockets | |
|---|---|
| Front | |
| Gate | |
| Back | |
| Subpockets | |
|---|---|
| FP-I | |
| FP-II | |
| BP-I-A | |
| BP-I-B | |
| BP-II-in | |
| BP-II-A-in | |
| BP-II-B-in | |
| BP-II-out | |
| BP-II-B | |
| BP-III | |
| BP-IV | |
| BP-V | |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 K 375 | 2 E 376 | 3 L 377 | 4 G 378 | 5 S 379 | 6 G 380 | 7 N 381 | 8 F 382 | 9 G 383 | 10 T 384 | 11 V 385 | 12 K 386 | 13 K 387 | 14 V 399 | 15 A 400 | 16 V 401 | 17 K 402 | 18 I 403 | 19 L 404 | 20 E 416 |
| ■ | ■ | ■ | ■ | ■ | |||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 L 417 | 22 L 418 | 23 A 419 | 24 E 420 | 25 A 421 | 26 N 422 | 27 V 423 | 28 M 424 | 29 Q 425 | 30 Q 426 | 31 L 427 | 32 D 428 | 33 P 430 | 34 Y 431 | 35 I 432 | 36 V 433 | 37 R 434 | 38 M 435 | 39 I 436 | 40 G 437 |
| ■ | |||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 I 438 | 42 M 445 | 43 L 446 | 44 V 447 | 45 M 448 | 46 E 449 | 47 M 450 | 48 A 451 | 49 E 452 | 50 L 453 | 51 G 454 | 52 P 455 | 53 L 456 | 54 N 457 | 55 K 458 | 56 Y 459 | 57 L 460 | 58 Q 461 | 59 Q 462 | 60 Y 484 |
| ■ | ■ | ■ | ■▲▲ | ■ | ■ | ■ | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 485 | 62 E 486 | 63 E 487 | 64 S 488 | 65 N 489 | 66 F 490 | 67 V 491 | 68 H 492 | 69 R 493 | 70 D 494 | 71 L 495 | 72 A 496 | 73 A 497 | 74 R 498 | 75 N 499 | 76 V 500 | 77 L 501 | 78 L 502 | 79 I 510 | 80 S 511 |
| ■ | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 512 | 82 F 513 | 83 G 514 | 84 L 515 | 85 S 516 | |||||||||||||||
Binding affinities
ChEMBL ID:CHEMBL475251Bioaffinities: 455 records for 269 kinase(s)
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | 3-phosphoinositide dependent protein kinase-1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | 3-phosphoinositide dependent protein kinase-1 | 8.1 | 8.1 | 8.1 | pKi | 1 |
| Homo sapiens | Activin receptor type-1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Activin receptor type-1B | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Adaptor-associated kinase | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | BMP-2-inducible protein kinase | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-1B | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | CaM kinase I alpha | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | CaM kinase I gamma | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | CaM kinase II alpha | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | CaM kinase II delta | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | CaM kinase II gamma | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | CaM kinase II gamma | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | cAMP-dependent protein kinase alpha-catalytic subunit | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | cAMP-dependent protein kinase alpha-catalytic subunit | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | cAMP-dependent protein kinase beta-1 catalytic subunit | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 7 | 7 | 7.9 | pKd | 2 |
| Homo sapiens | Cell division cycle 7-related protein kinase | 8.1 | 8.1 | 8.1 | pKi | 1 |
| Homo sapiens | cGMP-dependent protein kinase 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Chaperone activity of bc1 complex-like, mitochondrial | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Citron Rho-interacting kinase | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 8 | 8 | 8 | pEC50 | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 5.6 | 5.6 | 7.4 | pKd | 2 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | c-Jun N-terminal kinase 2 | 8 | 8 | 8 | pEC50 | 1 |
| Homo sapiens | c-Jun N-terminal kinase 2 | 5.7 | 5.7 | 7.3 | pKd | 2 |
| Homo sapiens | c-Jun N-terminal kinase 2 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 8 | 8 | 8 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 1 | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 5 | 5.8 | 5.8 | 5.8 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 1 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 2 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Discoidin domain-containing receptor 2 | 5.7 | 5.7 | 7.4 | pKd | 2 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 6 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 6.4 | 6.4 | 6.7 | pKd | 2 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Dual specificity testis-specific protein kinase 1 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Dual specificity tyrosine-phosphorylation-regulated kinase 4 | 5.8 | 5.8 | 5.8 | pKi | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 1 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 2 | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | Ephrin type-A receptor 3 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 4 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 5 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 6 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 7 | 7 | 7 | 7.4 | pKd | 2 |
| Homo sapiens | Ephrin type-A receptor 8 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 1 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 6 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 6.5 | 6 | 7.2 | pKd | 10 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 6.4 | 6.4 | 8 | pKd | 2 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.1 | 6.1 | 7.4 | pKd | 2 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 7.2 | 7.2 | 7.3 | pKd | 2 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 7.8 | 7.8 | 7.8 | pKi | 1 |
| Homo sapiens | Fibroblast growth factor receptor 4 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Focal adhesion kinase 1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Focal adhesion kinase 1 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Glycogen synthase kinase-3 alpha | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 alpha | 5.8 | 5.8 | 5.8 | pKi | 1 |
| Homo sapiens | Glycogen synthase kinase-3 beta | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 4 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 7 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.6 | 6.1 | 6.6 | pKd | 3 |
| Homo sapiens | Hepatocyte growth factor receptor | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 4 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase alpha subunit | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase beta subunit | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 6.8 | 6.8 | 7.9 | pKd | 2 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | Insulin-like growth factor I receptor | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Insulin-like growth factor I receptor | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | Insulin receptor | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Insulin receptor | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Insulin receptor-related protein | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Interferon-induced, double-stranded RNA-activated protein kinase | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 6.2 | 6.2 | 8 | pKd | 2 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 8 | 8 | 8 | pKi | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 7.4 | 7.4 | 8 | pKd | 2 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 7.4 | 7.4 | 7.6 | pKd | 2 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 7.5 | 7.5 | 7.5 | pKi | 1 |
| Homo sapiens | Leukocyte tyrosine kinase receptor | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | LIM domain kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | LIM domain kinase 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | MAP kinase-interacting serine/threonine-protein kinase MNK1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | MAP kinase p38 delta | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | MAP kinase p38 delta | 5.4 | 5.4 | 5.4 | pKi | 1 |
| Homo sapiens | MAP kinase p38 gamma | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | MAP kinase p38 gamma | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | MAP kinase signal-integrating kinase 2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | MAP kinase signal-integrating kinase 2 | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 7 | 7 | 7 | pKi | 1 |
| Mus musculus | Mast/stem cell growth factor receptor Kit | 7.3 | 7.3 | 7.3 | pEC50 | 1 |
| Homo sapiens | Mitogen-activated protein kinase 15 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 10 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 10 | 8.4 | 8.4 | 8.4 | pKi | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 11 | 8 | 7.5 | 8 | pKd | 3 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Muscle, skeletal receptor tyrosine protein kinase | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase family member 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase, smooth muscle | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 6.8 | 6.8 | 7.6 | pKd | 2 |
| Homo sapiens | NT-3 growth factor receptor | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | NT-3 growth factor receptor | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 1 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 2 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | PI3-kinase p110-delta subunit | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | PI4-kinase beta subunit | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 7.3 | 7.3 | 7.3 | pKi | 1 |
| Homo sapiens | Protein kinase C delta | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Protein kinase C gamma | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | Protein kinase C nu | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | Protein kinase N1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Protein kinase N2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Protein tyrosine kinase 2 beta | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 8.2 | 8.2 | 8.2 | pKi | 1 |
| Homo sapiens | Putative uncharacterized serine/threonine-protein kinase SgK110 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 4 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 7.5 | 7.5 | 7.5 | pKi | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Rho-associated protein kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Rhodopsin kinase | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 1 | 5.4 | 5.4 | 6.3 | pKd | 4 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 5.1 | 5.1 | 5.1 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 4 | 7.4 | 7.4 | 7.4 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 5 | 6.8 | 6.8 | 6.8 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 11 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 16 | 7 | 7 | 8.8 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 17A | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17A | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17B | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 7.6 | 7.6 | 7.6 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase 25 | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 32A | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 33 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 35 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 36 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 38 | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 6.8 | 6.8 | 7.5 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 6.3 | 6.3 | 6.3 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 7 | 7 | 7 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-C | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase B-raf | 6.4 | 6.4 | 6.6 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase D2 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK3 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase/endoribonuclease IRE1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase GAK | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase LATS2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MARK1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Nek1 | 6.2 | 6.2 | 6.8 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase Nek11 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK2 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Nek3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Nek4 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Nek4 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Nek5 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK6 | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK7 | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK9 | 6.8 | 6.8 | 7.8 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase NIM1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase OSR1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 1 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 6.3 | 6.3 | 7 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK6 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK7 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PIM3 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Mycobacterium tuberculosis | Serine/threonine-protein kinase pknB | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK2 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK3 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK3 | 7.3 | 7.3 | 7.3 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 6.8 | 6.8 | 8.4 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 8 | 8 | 8 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase RAF | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO3 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIPK2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SBK1 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.1 | 6.1 | 7.1 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 7.6 | 7.6 | 7.6 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK3 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.5 | 6.5 | 7.6 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase TNNI3K | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase tousled-like 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase tousled-like 2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK2 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK3 | 6.6 | 6.6 | 8.2 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase WEE1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 8.2 | 6.4 | 8.6 | pKd | 8 |
| Homo sapiens | Testis-specific serine/threonine-protein kinase 1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Testis-specific serine/threonine-protein kinase 1 | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | TGF-beta receptor type I | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | TGF-beta receptor type II | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | TRAF2- and NCK-interacting kinase | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 6.4 | 5.8 | 6.8 | pKd | 11 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 8.2 | 8.2 | 8.2 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BRK | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BRK | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase CSK | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FER | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FER | 7.9 | 7.9 | 7.9 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase FES | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 7.9 | 7.9 | 7.9 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | 7.7 | 7.7 | 7.7 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 7.9 | 7.9 | 7.9 | pEC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 8.2 | 8.2 | 8.2 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 8.5 | 8.5 | 8.5 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 7.4 | 7.4 | 7.4 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 6.1 | 6.1 | 6.1 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase LCK | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 6.1 | 6.1 | 6.1 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 7.9 | 7.9 | 7.9 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 8 | 8 | 8 | pEC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 9.2 | 7.8 | 9.4 | pKd | 9 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 7.1 | 7.1 | 7.4 | pEC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 8.3 | 8.3 | 8.3 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 8.4 | 7.4 | 8.7 | pKd | 5 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 7.9 | 7.9 | 7.9 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 8.2 | 8.2 | 8.2 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase Srms | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 7.3 | 5.4 | 8 | pEC50 | 13 |
| Homo sapiens | Tyrosine-protein kinase SYK | 7.2 | 5.5 | 8.3 | pIC50 | 8 |
| Homo sapiens | Tyrosine-protein kinase SYK | 5.9 | 5.9 | 7.7 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase SYK | 7.5 | 7.5 | 8.2 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase TEC | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 6.7 | 6.7 | 6.7 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 7.8 | 7.8 | 7.8 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase YES | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ZAP-70 | 7.4 | 7.4 | 7.4 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase ZAP-70 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Uncharacterized aarF domain-containing protein kinase 1 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Uncharacterized aarF domain-containing protein kinase 4 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 7.6 | 7.6 | 7.6 | pKi | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.4 | 7.4 | 7.4 | pEC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.7 | 7.7 | 7.7 | pKi | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Wee1-like protein kinase 2 | 5 | 5 | 5 | pKd | 1 |