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Search results (144 entries covering 71 PDB structures)
#
Kinase
Family
Group
PDB
Chain
(Alternate) Model
Orthosteric ligand
Organism
Details
File
IRAK4
IRAK
TKL
4u9a
A
staurosporine
Human
1751
IRAK4
IRAK
TKL
4u9a
B
staurosporine
Human
1792
SYK
Syk
TK
1xbc
A
A
staurosporine
Human
1165
IRAK4
IRAK
TKL
2oic
A
staurosporine
Human
1739
ERN1 (IRE1)
IRE
Other
4yzc
B
B
staurosporine
Human
6231
STK16 (MPSK1)
NAK
Other
2buj
A
staurosporine
Human
2229
MAP3K5
STE11
STE
4bf2
A
staurosporine
Human
4743
LCK
Src
TK
1qpj
A
staurosporine
Human
2283
CSK
Csk
TK
1byg
A
staurosporine
Human
2943
STK16 (MPSK1)
NAK
Other
2buj
B
staurosporine
Human
2230
MAP3K5
STE11
STE
2clq
B
B
staurosporine
Human
4732
IRAK4
IRAK
TKL
2oic
D
staurosporine
Human
1755
EPHB4 (EphB4)
Eph
TK
2yn8
B
staurosporine
Human
349
CHEK1 (CHK1)
CAMKL
CAMK
7ako
B
A
staurosporine
Human
13492
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b1u
C
A
staurosporine
Human
9847
PIK3CG (p110g)
PIK
Atypical
1e8z
A
staurosporine
Human
9228
MAP3K5
STE11
STE
2clq
A
B
staurosporine
Human
4736
LIMK1
LISK
TKL
3s95
A
A
staurosporine
Human
1246
IRAK4
IRAK
TKL
2nry
D
A
staurosporine
Human
1789
LIMK1
LISK
TKL
3s95
A
B
staurosporine
Human
1248
PRKAA1 (AMPKa1)
CAMKL
CAMK
6c9j
A
staurosporine
Human
10717
PRKAA1 (AMPKa1)
CAMKL
CAMK
4rer
A
staurosporine
Human
121
PRKAA1 (AMPKa1)
CAMKL
CAMK
4rew
A
staurosporine
Human
124
PRKAA1 (AMPKa1)
CAMKL
CAMK
6c9g
A
staurosporine
Human
10715
PRKAA1 (AMPKa1)
CAMKL
CAMK
6c9h
A
staurosporine
Human
10714
PRKAA1 (AMPKa1)
CAMKL
CAMK
6c9f
A
staurosporine
Human
10716
IRAK4
IRAK
TKL
2nry
B
A
staurosporine
Human
1758
PDPK1 (PDK1)
PDK1
AGC
1oky
A
A
staurosporine
Human
3164
Prkaa1 (AMPKa1)
CAMKL
CAMK
5ufu
A
staurosporine
Mouse
7590
CDK2
CDK
CMGC
4ez7
A
staurosporine
Human
4240
PAK4
STE20
STE
5ved
A
staurosporine
Human
8570
ERN1 (IRE1)
IRE
Other
4yzc
A
A
staurosporine
Human
6235
IRAK4
IRAK
TKL
2nry
C
A
staurosporine
Human
1779
GSK3B
GSK
CMGC
1q3d
B
staurosporine
Human
752
TGFBR1 (TGFbR1)
STKR
TKL
5e8w
A
A
staurosporine
Human
6611
EPHB4 (EphB4)
Eph
TK
2yn8
A
staurosporine
Human
352
EPHB4 (EphB4)
Eph
TK
3zew
B
B
staurosporine
Human
357
SYK
Syk
TK
1xbc
A
B
staurosporine
Human
1207
STK32A (YANK1)
YANK
AGC
4fr4
A
B
staurosporine
Human
4690
CHEK1 (CHK1)
CAMKL
CAMK
7ako
A
B
staurosporine
Human
13495
ERN1 (IRE1)
IRE
Other
4yzc
A
B
staurosporine
Human
6232
CHEK1 (CHK1)
CAMKL
CAMK
5oor
A
staurosporine
Human
8603
RIPK2
RIPK
TKL
5ng2
A
B
staurosporine
Human
8056
RIPK2
RIPK
TKL
5ng2
A
A
staurosporine
Human
8050
CHEK1 (CHK1)
CAMKL
CAMK
1nvr
A
staurosporine
Human
1585
CDK2
CDK
CMGC
7nvq
A
staurosporine
Human
13627
STK24 (MST3)
STE20
STE
3ckx
A
staurosporine
Human
5599
STK24 (MST3)
STE20
STE
4qmy
A
staurosporine
Human
5592
RPS6KA1 (RSK3)
RSK
AGC
2z7r
A
staurosporine
Human
2777
STK32A (YANK1)
YANK
AGC
4fr4
E
B
staurosporine
Human
4685
LCK
Src
TK
1qpd
A
staurosporine
Human
2267
MAP3K5
STE11
STE
2clq
A
A
staurosporine
Human
4740
MAPKAPK2
MAPKAPK
CAMK
1nxk
A
staurosporine
Human
1342
MKNK2 (MNK2)
MAPKAPK
CAMK
2hw7
A
staurosporine
Human
764
MAP2K6
STE7
STE
3fme
A
staurosporine
Human
1231
PRKAA2 (AMPKa2)
CAMKL
CAMK
5iso
C
staurosporine
Human
7980
PRKAA2 (AMPKa2)
CAMKL
CAMK
5ezv
A
A
staurosporine
Human
6424
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b2e
A
staurosporine
Human
9851
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b1u
C
B
staurosporine
Human
9850
PRKAA2 (AMPKa2)
CAMKL
CAMK
5iso
A
staurosporine
Human
7981
PRKAA2 (AMPKa2)
CAMKL
CAMK
5ezv
C
A
staurosporine
Human
6430
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b1u
A
A
staurosporine
Human
9848
PRKAA2 (AMPKa2)
CAMKL
CAMK
4cff
C
staurosporine
Human
190
PRKAA2 (AMPKa2)
CAMKL
CAMK
5ezv
C
B
staurosporine
Human
6426
TGFBR2 (TGFbR2)
STKR
TKL
5e8y
A
staurosporine
Human
6627
TTK
TTK
Other
3hmo
A
staurosporine
Human
4707
PIM1
PIM
CAMK
1yhs
A
staurosporine
Human
2444
FES
Fer
TK
3cd3
A
A
staurosporine
Human
2814
FES
Fer
TK
3cbl
A
B
staurosporine
Human
2811
IRAK4
IRAK
TKL
2nry
A
A
staurosporine
Human
1753
FES
Fer
TK
3bkb
A
B
staurosporine
Human
2813
FES
Fer
TK
3bkb
A
A
staurosporine
Human
2810
CDK2
CDK
CMGC
1aq1
A
staurosporine
Human
4267
FES
Fer
TK
3cd3
A
B
staurosporine
Human
2815
ERN1 (IRE1)
IRE
Other
4yzc
B
A
staurosporine
Human
6227
PRKAA2 (AMPKa2)
CAMKL
CAMK
4cfe
C
staurosporine
Human
192
EPHB4 (EphB4)
Eph
TK
3zew
A
B
staurosporine
Human
377
PRKAA2 (AMPKa2)
CAMKL
CAMK
4cff
A
staurosporine
Human
191
EPHB4 (EphB4)
Eph
TK
3zew
B
A
staurosporine
Human
351
CDK2
CDK
CMGC
4erw
A
staurosporine
Human
4370
Ripk4 (ANKRD3)
RIPK
TKL
5wnl
A
staurosporine
Mouse
9891
LYN
Src
TK
3a4o
X
staurosporine
Human
1812
ZAP70
Syk
TK
1u59
A
A
staurosporine
Human
2734
ZAP70
Syk
TK
1u59
A
B
staurosporine
Human
2733
RIPK2
RIPK
TKL
5ng2
B
A
staurosporine
Human
8053
IRAK4
IRAK
TKL
4u97
A
staurosporine
Human
1754
RIPK2
RIPK
TKL
5ng2
B
B
staurosporine
Human
8052
MASTL
MAST
AGC
5loh
B
A
staurosporine
Human
7088
MASTL
MAST
AGC
5loh
B
B
staurosporine
Human
7087
MASTL
MAST
AGC
5loh
A
B
staurosporine
Human
7085
MASTL
MAST
AGC
5loh
A
A
staurosporine
Human
7086
FES
Fer
TK
3cbl
A
A
staurosporine
Human
2808
GSK3B
GSK
CMGC
1q3d
A
staurosporine
Human
705
ALK
ALK
TK
3lcs
A
A
staurosporine
Human
5381
MAP3K5
STE11
STE
2clq
B
A
staurosporine
Human
4755
MAP3K5
STE11
STE
4bf2
B
staurosporine
Human
4745
ALK
ALK
TK
3lcs
A
B
staurosporine
Human
5376
TGFBR1 (TGFbR1)
STKR
TKL
5e8x
A
B
staurosporine
Human
6617
STK32A (YANK1)
YANK
AGC
4fr4
C
A
staurosporine
Human
4684
STK32A (YANK1)
YANK
AGC
4fr4
B
A
staurosporine
Human
4692
PDPK1 (PDK1)
PDK1
AGC
1oky
A
B
staurosporine
Human
3195
IRAK4
IRAK
TKL
4u97
B
staurosporine
Human
1742
IRAK4
IRAK
TKL
2oic
B
staurosporine
Human
1752
LIMK1
LISK
TKL
3s95
B
B
staurosporine
Human
1247
LIMK1
LISK
TKL
3s95
B
A
staurosporine
Human
1245
PRKCQ (PKCt)
PKC
AGC
1xjd
A
staurosporine
Human
5357
ITK
Tec
TK
1sm2
A
staurosporine
Human
74
ITK
Tec
TK
1snu
A
staurosporine
Human
82
IRAK4
IRAK
TKL
2nry
D
B
staurosporine
Human
1746
ITK
Tec
TK
1sm2
B
staurosporine
Human
73
IRAK4
IRAK
TKL
2nry
C
B
staurosporine
Human
1750
ITK
Tec
TK
1snu
B
staurosporine
Human
33
CHEK1 (CHK1)
CAMKL
CAMK
7ako
A
A
staurosporine
Human
13490
IRAK4
IRAK
TKL
2nry
B
B
staurosporine
Human
1772
IRAK4
IRAK
TKL
2oic
C
staurosporine
Human
1734
IRAK4
IRAK
TKL
2nry
A
B
staurosporine
Human
1777
STK32A (YANK1)
YANK
AGC
4fr4
B
B
staurosporine
Human
4695
STK32A (YANK1)
YANK
AGC
4fr4
F
B
staurosporine
Human
4686
CSK
Csk
TK
3d7t
A
staurosporine
Human
2941
DAPK1
DAPK
CAMK
1wvy
A
staurosporine
Human
5661
STK32A (YANK1)
YANK
AGC
4fr4
E
A
staurosporine
Human
4689
STK32A (YANK1)
YANK
AGC
4fr4
C
B
staurosporine
Human
4694
STK32A (YANK1)
YANK
AGC
4fr4
D
A
staurosporine
Human
4688
STK32A (YANK1)
YANK
AGC
4fr4
F
A
staurosporine
Human
4691
EPHB4 (EphB4)
Eph
TK
3zew
A
A
staurosporine
Human
373
STK32A (YANK1)
YANK
AGC
4fr4
D
B
staurosporine
Human
4687
CHEK1 (CHK1)
CAMKL
CAMK
7ako
B
B
staurosporine
Human
13496
STK32A (YANK1)
YANK
AGC
4fr4
A
A
staurosporine
Human
4693
MAPKAPK2
MAPKAPK
CAMK
1nxk
C
staurosporine
Human
1312
MAPKAPK2
MAPKAPK
CAMK
1nxk
D
staurosporine
Human
1334
MAPKAPK2
MAPKAPK
CAMK
2pzy
C
staurosporine
Human
1279
MAPKAPK2
MAPKAPK
CAMK
1nxk
B
staurosporine
Human
1292
FES
Fer
TK
3bkb
A
C
staurosporine
Human
2812
FYN
Src
TK
2dq7
X
staurosporine
Human
1941
RPS6KB1 (p70S6K)
RSK
AGC
3a61
A
staurosporine
Human
1846
RPS6KB1 (p70S6K)
RSK
AGC
3a62
A
staurosporine
Human
1867
TGFBR1 (TGFbR1)
STKR
TKL
5e8x
A
A
staurosporine
Human
6615
TGFBR1 (TGFbR1)
STKR
TKL
5e8w
A
B
staurosporine
Human
6614
RPS6KB1 (p70S6K)
RSK
AGC
4rlo
B
staurosporine
Human
7220
RPS6KB1 (p70S6K)
RSK
AGC
3a60
B
staurosporine
Human
1856
RPS6KB1 (p70S6K)
RSK
AGC
3a60
A
staurosporine
Human
1852
PRKAA2 (AMPKa2)
CAMKL
CAMK
5ezv
A
B
staurosporine
Human
6428
PRKAA2 (AMPKa2)
CAMKL
CAMK
6b1u
A
B
staurosporine
Human
9849
PRKAA2 (AMPKa2)
CAMKL
CAMK
4cfe
A
staurosporine
Human
195
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