| TYK2-b | JakB | TK | 6nsl | B | B | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 11953 | |
| TYK2-b | JakB | TK | 7k7o | A | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 13835 | |
| TYK2-b | JakB | TK | 7k7q | A | B | 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamide | Human | 13836 | |
| TYK2-b | JakB | TK | 6nzr | B | B | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11500 | |
| TYK2-b | JakB | TK | 6nzf | B | A | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11451 | |
| TYK2-b | JakB | TK | 7k7o | A | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 13837 | |
| TYK2-b | JakB | TK | 6nzq | A | B | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11499 | |
| TYK2-b | JakB | TK | 4wov | B | B | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | 2197 | |
| TYK2-b | JakB | TK | 8s99 | A | B | (8s)-n-[(1r,2s)-2-fluorocyclopropyl]-5-{[(1m,2'm)-3'-fluoro-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14850 | |
| TYK2-b | JakB | TK | 8s9a | A | B | (8s)-n-[(1r,2r)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1p,2'p)-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14851 | |
| TYK2-b | JakB | TK | 6nzh | B | A | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11447 | |
| TYK2-b | JakB | TK | 5c03 | B | B | phosphothiophosphoric acid-adenylate ester | Human | 6045 | |
| TYK2-b | JakB | TK | 5c03 | B | A | phosphothiophosphoric acid-adenylate ester | Human | 6042 | |
| TYK2-b | JakB | TK | 6nsl | B | A | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 11955 | |
| TYK2-b | JakB | TK | 6nzr | A | B | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11503 | |
| TYK2-b | JakB | TK | 8tb6 | A | A | n-[(3m)-3-{6-[(3r)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]urea | Human | 14956 | |
| TYK2-b | JakB | TK | 8tb5 | A | B | n-{(3p)-3-[3-(dimethylsulfamoyl)phenyl]-1h-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide | Human | 14955 | |
| TYK2-b | JakB | TK | 8tb6 | A | B | n-[(3m)-3-{6-[(3r)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]urea | Human | 14957 | |
| TYK2-b | JakB | TK | 6nze | A | B | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11444 | |
| TYK2-b | JakB | TK | 5tkd | A | B | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 7326 | |
| TYK2-b | JakB | TK | 6nzp | B | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11496 | |
| TYK2-b | JakB | TK | 6nzq | B | A | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11495 | |
| TYK2-b | JakB | TK | 6nzf | A | B | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11449 | |
| TYK2-b | JakB | TK | 8tb5 | A | A | n-{(3p)-3-[3-(dimethylsulfamoyl)phenyl]-1h-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide | Human | 14958 | |
| TYK2-b | JakB | TK | 7ax4 | B | | 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide | Human | 13498 | |
| TYK2-b | JakB | TK | 6nzp | A | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11501 | |
| TYK2-b | JakB | TK | 5c03 | A | A | phosphothiophosphoric acid-adenylate ester | Human | 6043 | |
| TYK2-b | JakB | TK | 6nzr | A | A | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11505 | |
| TYK2-b | JakB | TK | 4wov | A | B | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | 2199 | |
| TYK2-b | JakB | TK | 6nzh | A | A | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11450 | |
| TYK2-b | JakB | TK | 6nzf | B | B | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11445 | |
| TYK2-b | JakB | TK | 6nzh | B | B | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11452 | |
| TYK2-b | JakB | TK | 6nsl | A | A | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 11952 | |
| TYK2-b | JakB | TK | 3zon | A | | 5-phenyl-2-ureidothiophene-3-carboxamide | Human | 2200 | |
| TYK2-b | JakB | TK | 6nzh | A | B | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11442 | |
| TYK2-b | JakB | TK | 6nzp | B | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11497 | |
| TYK2-b | JakB | TK | 7ax4 | A | | 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide | Human | 13499 | |
| TYK2-b | JakB | TK | 6nze | A | A | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11453 | |
| TYK2-b | JakB | TK | 4wov | A | A | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | 2196 | |
| TYK2-b | JakB | TK | 6nzr | B | A | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11498 | |
| TYK2-b | JakB | TK | 5c03 | A | B | phosphothiophosphoric acid-adenylate ester | Human | 6044 | |
| TYK2-b | JakB | TK | 5tkd | B | B | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 7324 | |
| TYK2-b | JakB | TK | 6nzq | A | A | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11502 | |
| TYK2-b | JakB | TK | 4oli | A | | 2-chloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 2198 | |
| TYK2-b | JakB | TK | 6nsl | A | B | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 11954 | |
| TYK2-b | JakB | TK | 6nze | B | A | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11448 | |
| TYK2-b | JakB | TK | 6nzf | A | A | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11446 | |
| TYK2-b | JakB | TK | 5tkd | A | A | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 7323 | |
| TYK2-b | JakB | TK | 7k7q | A | A | 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamide | Human | 13838 | |
| TYK2-b | JakB | TK | 5c01 | A | | unknown ligand | Human | 7222 | |
| TYK2-b | JakB | TK | 4wov | B | A | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | 2195 | |
| TYK2-b | JakB | TK | 6nzq | B | B | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11506 | |
| TYK2-b | JakB | TK | 6nze | B | B | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11443 | |
| TYK2-b | JakB | TK | 5c01 | B | | unknown ligand | Human | 7223 | |
| TYK2-b | JakB | TK | 6nzp | A | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11504 | |
| TYK2-b | JakB | TK | 5tkd | B | A | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 7325 | |
| TYK2-b | JakB | TK | 8s98 | A | A | (8s)-n-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14849 | |
| TYK2-b | JakB | TK | 8s98 | A | B | (8s)-n-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14846 | |
| TYK2-b | JakB | TK | 8s99 | A | A | (8s)-n-[(1r,2s)-2-fluorocyclopropyl]-5-{[(1m,2'm)-3'-fluoro-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14847 | |
| TYK2-b | JakB | TK | 8s9a | A | A | (8s)-n-[(1r,2r)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1p,2'p)-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14848 | |
