KLIFS - the structural kinase database

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	4rj7	A	B	2,6-dichloro-n-{2-[(2-{[(2s)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide	Human	828	0.47
EGFR	EGFR	TK	4rj7	A	A	2,6-dichloro-n-{2-[(2-{[(2s)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide	Human	793	0.47
TGFBR1 (TGFbR1)	STKR	TKL	5fri	A	B	n-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide	Human	6893	0.45
JAK2	JakA	TK	4gmy	A		2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	3684	0.77
TYK2	JakA	TK	4gih	A	A	2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	3339	0.77
AURKA (AurA)	Aur	Other	2np8	A		n-{3-[(4-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]phenyl}cyclopropanecarboxamide	Human	2075	0.42
TYK2-b	JakB	TK	4oli	A		2-chloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	2198	0.60
TYK2	JakA	TK	4gj3	A		2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide	Human	3345	0.75
TYK2	JakA	TK	4gj2	A		2,6-dichloro-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide	Human	3344	1.00
TYK2	JakA	TK	4gih	A	B	2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	3332	0.77
TYK2	JakA	TK	4gii	A		2,6-dichloro-4-cyano-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide	Human	3331	0.59
TGFBR1 (TGFbR1)	STKR	TKL	5fri	A	A	n-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide	Human	6894	0.45