KLIFS - the structural kinase database

Search results (47 entries covering 32 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	7u9a	A		4-(5-chloro-4-fluoro-2-hydroxyanilino)-7-methoxyquinazolin-6-ol	Human	14527	0.48
MAPK14 (p38a)	MAPK	CMGC	1di9	A		4-[3-methylsulfanylanilino]-6,7-dimethoxyquinazoline	Human	5251	0.70
EGFR	EGFR	TK	4lrm	B		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	867	0.45
EGFR	EGFR	TK	4ll0	A		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	804	0.45
AURKA (AurA)	Aur	Other	2c6e	A		n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide	Human	1989	0.46
EGFR	EGFR	TK	4hjo	A		[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	835	0.55
EGFR	EGFR	TK	4ll0	B		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	796	0.45
EGFR	EGFR	TK	4lrm	C		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	781	0.45
EGFR	EGFR	TK	7a6j	A	B	1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14124	0.42
MERTK (MER)	Axl	TK	7avy	A		n-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine	Human	13369	0.43
EGFR	EGFR	TK	1m17	A	B	[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	905	0.55
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.45
EGFR	EGFR	TK	7a6j	A	A	1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14125	0.42
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.45
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.45
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.45
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.45
TTBK2	TTBK	CK1	6u0k	B	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12049	1.00
TTBK2	TTBK	CK1	6u0k	A	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12046	1.00
CDK2	CDK	CMGC	1di8	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	4577	1.00
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.45
EPHB3 (EphB3)	Eph	TK	5l6p	A		~{n}-(4-phenylazanylquinazolin-7-yl)ethanamide	Human	6937	0.46
EGFR	EGFR	TK	2j5f	A		n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide	Human	862	0.44
ABL1	Abl	TK	8ssn	A		6,7-dimethoxy-n-(4-phenoxyphenyl)quinazolin-4-amine	Human	14878	0.64
EPHB3 (EphB3)	Eph	TK	5l6o	A		1-(4-phenylazanylquinazolin-7-yl)ethanone	Human	6938	0.47
EGFR	EGFR	TK	8f1y	A		1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14940	0.42
EGFR	EGFR	TK	8f1w	A		1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14944	0.42
PIK3CG (p110g)	PIK	Atypical	3qaq	A		[(4-{2-[(3-hydroxyphenyl)amino]-1h-benzimidazol-1-yl}-1,3,5-triazin-2-yl)amino]acetonitrile	Human	9211	0.41
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.45
EGFR	EGFR	TK	4lrm	D		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	786	0.45
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.45
EGFR	EGFR	TK	4lrm	A		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	901	0.45
EGFR	EGFR	TK	4lrm	E		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	825	0.45
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.45
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.45
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.45
AURKA (AurA)	Aur	Other	2c6e	B		n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide	Human	2046	0.46
KDR	VEGFR	TK	2p2h	A		4-(2-anilinopyridin-3-yl)-n-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine	Human	5310	0.42
RET	Ret	TK	5amn	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	6412	1.00
KSR2	RAF	TKL	5kkr	B		6,7-dimethoxy-~{n}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine	Human	7027	0.52
TTBK1	TTBK	CK1	4btk	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	771	1.00
RET	Ret	TK	2ivu	A		4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]aniline	Human	3364	0.41
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.45
EGFR	EGFR	TK	1m17	A	A	[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	873	0.55
EGFR	EGFR	TK	4lqm	A		n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide	Human	785	0.44
TTBK2	TTBK	CK1	6u0k	B	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12047	1.00
TTBK2	TTBK	CK1	6u0k	A	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12048	1.00