| FGFR4 | FGFR | TK | 6v9c | A | A | n-[(3r,4s)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide | Human | 12096 | 0.41 | |
| Abl1 (ABL1) | Abl | TK | 1opk | A | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Mouse | 5709 | 0.72 | |
| Abl1 (ABL1) | Abl | TK | 1m52 | A | | 6-(2,6-dichloro-phenyl)-8-methyl-2-(3-methylsulfanyl-phenylamino)-8h-pyrido[2,3-d]pyrimidin-7-one | Mouse | 5720 | 0.73 | |
| EPHA2 (EphA2) | Eph | TK | 5ia3 | A | B | 6-(2,6-dichloro-phenyl)-8-methyl-2-(3-methylsulfanyl-phenylamino)-8h-pyrido[2,3-d]pyrimidin-7-one | Human | 7184 | 0.73 | |
| Abl1 (ABL1) | Abl | TK | 1m52 | B | | 6-(2,6-dichloro-phenyl)-8-methyl-2-(3-methylsulfanyl-phenylamino)-8h-pyrido[2,3-d]pyrimidin-7-one | Mouse | 5715 | 0.73 | |
| EPHA2 (EphA2) | Eph | TK | 5ia3 | A | A | 6-(2,6-dichloro-phenyl)-8-methyl-2-(3-methylsulfanyl-phenylamino)-8h-pyrido[2,3-d]pyrimidin-7-one | Human | 7193 | 0.73 | |
| STK24 (MST3) | STE20 | STE | 8bzj | A | B | 8-(4-azanylbutyl)-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14583 | 0.41 | |
| STK24 (MST3) | STE20 | STE | 8bzj | A | A | 8-(4-azanylbutyl)-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14586 | 0.41 | |
| STK24 (MST3) | STE20 | STE | 8bzi | A | B | 8-(4-azanylbutyl)-6-[2,5-bis(fluoranyl)-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14584 | 0.41 | |
| ABL1 | Abl | TK | 1opl | A | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1104 | 0.72 | |
| FGFR4 | FGFR | TK | 6v9c | A | B | n-[(3r,4s)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide | Human | 12095 | 0.41 | |
| SYK | Syk | TK | 3tud | A | | n-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide | Human | 1176 | 0.49 | |
| ABL1 | Abl | TK | 2hzi | B | A | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1108 | 1.00 | |
| STK24 (MST3) | STE20 | STE | 8bzi | A | A | 8-(4-azanylbutyl)-6-[2,5-bis(fluoranyl)-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14585 | 0.41 | |
| BRAF | RAF | TKL | 4e4x | B | | n-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide | Human | 3104 | 0.44 | |
| BRAF | RAF | TKL | 4e4x | A | | n-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide | Human | 3051 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 8bin | A | A | 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14514 | 0.45 | |
| EPHA2 (EphA2) | Eph | TK | 8bin | A | B | 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14515 | 0.45 | |
| EPHA2 (EphA2) | Eph | TK | 8bin | A | C | 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14512 | 0.45 | |
| ABL1 | Abl | TK | 2fo0 | A | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1073 | 0.72 | |
| ABL1 | Abl | TK | 2g2h | B | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1089 | 0.72 | |
| ABL1 | Abl | TK | 2hzi | A | A | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1102 | 1.00 | |
| ABL1 | Abl | TK | 1opl | B | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1086 | 0.72 | |
| ABL1 | Abl | TK | 2hzi | B | B | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1055 | 1.00 | |
| WEE1 (Wee1) | WEE | Other | 5vc5 | A | B | 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 8333 | 0.61 | |
| WEE1 (Wee1) | WEE | Other | 5vc5 | A | A | 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 8332 | 0.61 | |
| ABL1 | Abl | TK | 2hzi | A | B | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1087 | 1.00 | |
| ABL1 | Abl | TK | 2g2h | A | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1106 | 0.72 | |
| PAK4 | STE20 | STE | 5vee | A | | 6-(2,4-dichlorophenyl)-8-ethyl-2-{[3-fluoro-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8h)-one | Human | 8572 | 0.45 | |
