| VRK1 | VRK | CK1 | 5uvf | A | | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 7521 | 0.40 | |
| VRK1 | VRK | CK1 | 6dd4 | D | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5h)-one | Human | 9938 | 0.41 | |
| JAK2-b | JakB | TK | 6g3c | A | B | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | Human | 10976 | 0.43 | |
| VRK2 | VRK | CK1 | 5uu1 | A | | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 7499 | 0.40 | |
| RPS6KA3 (RSK2) | RSK | AGC | 5d9k | B | | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 5987 | 0.40 | |
| VRK1 | VRK | CK1 | 6cmm | D | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9764 | 0.43 | |
| VRK1 | VRK | CK1 | 6csw | B | B | (7r)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5h)-one | Human | 9808 | 0.43 | |
| VRK1 | VRK | CK1 | 6bp0 | D | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one | Human | 8739 | 0.45 | |
| VRK1 | VRK | CK1 | 6cqh | D | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9771 | 0.42 | |
| VRK1 | VRK | CK1 | 6vzh | D | | (7~{r})-2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7-dimethyl-8-prop-2-ynyl-7~{h}-pteridin-6-one | Human | 12055 | 0.43 | |
| VRK1 | VRK | CK1 | 6dd4 | D | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5h)-one | Human | 9934 | 0.41 | |
| RPS6KA3 (RSK2) | RSK | AGC | 5d9k | A | | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 5988 | 0.40 | |
| VRK1 | VRK | CK1 | 6cfm | B | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9725 | 0.43 | |
| VRK1 | VRK | CK1 | 6bp0 | B | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one | Human | 8740 | 0.45 | |
| VRK1 | VRK | CK1 | 6cfm | B | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9724 | 0.43 | |
| VRK1 | VRK | CK1 | 6btw | D | A | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one | Human | 9415 | 1.00 | |
| VRK1 | VRK | CK1 | 6cfm | D | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9721 | 0.43 | |
| VRK1 | VRK | CK1 | 6bru | B | B | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one | Human | 9087 | 0.45 | |
| VRK1 | VRK | CK1 | 6cqh | D | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9767 | 0.42 | |
| VRK1 | VRK | CK1 | 6vxu | B | | (7r)-8-(cyclopropylmethyl)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 13362 | 0.41 | |
| VRK1 | VRK | CK1 | 6cfm | A | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9723 | 0.43 | |
| VRK1 | VRK | CK1 | 5uvf | D | | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 7522 | 0.40 | |
| VRK1 | VRK | CK1 | 6cmm | B | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9761 | 0.43 | |
| VRK1 | VRK | CK1 | 6dd4 | B | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5h)-one | Human | 9933 | 0.41 | |
| VRK1 | VRK | CK1 | 6cmm | B | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9766 | 0.43 | |
| VRK1 | VRK | CK1 | 6csw | D | A | (7r)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5h)-one | Human | 9817 | 0.43 | |
| VRK1 | VRK | CK1 | 6bp0 | D | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one | Human | 8745 | 0.45 | |
| VRK1 | VRK | CK1 | 6vzh | B | | (7~{r})-2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7-dimethyl-8-prop-2-ynyl-7~{h}-pteridin-6-one | Human | 12056 | 0.43 | |
| MELK | CAMKL | CAMK | 6vxr | A | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 12644 | 0.43 | |
| MELK | CAMKL | CAMK | 6vxr | A | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 12645 | 0.43 | |
| VRK1 | VRK | CK1 | 6bp0 | B | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one | Human | 8741 | 0.45 | |
| JAK2-b | JakB | TK | 5ut1 | A | B | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 8049 | 0.40 | |
| VRK1 | VRK | CK1 | 6cqh | A | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9768 | 0.42 | |
| VRK1 | VRK | CK1 | 5uvf | B | | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 7523 | 0.40 | |
| VRK1 | VRK | CK1 | 6csw | B | A | (7r)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5h)-one | Human | 9812 | 0.43 | |
| JAK2-b | JakB | TK | 6g3c | B | A | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | Human | 10977 | 0.43 | |
| JAK2-b | JakB | TK | 6g3c | A | A | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | Human | 10978 | 0.43 | |
| JAK2-b | JakB | TK | 5ut1 | A | A | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 8046 | 0.40 | |
| JAK2-b | JakB | TK | 6g3c | B | B | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | Human | 10975 | 0.43 | |
| JAK2-b | JakB | TK | 5wik | B | | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 10387 | 0.40 | |
| VRK1 | VRK | CK1 | 6csw | D | B | (7r)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5h)-one | Human | 9809 | 0.43 | |
| VRK1 | VRK | CK1 | 6bru | B | A | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one | Human | 9088 | 0.45 | |
| VRK1 | VRK | CK1 | 6cmm | D | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9759 | 0.43 | |
| VRK1 | VRK | CK1 | 6cfm | D | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9722 | 0.43 | |
| VRK1 | VRK | CK1 | 6btw | A | B | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one | Human | 9425 | 1.00 | |
| VRK1 | VRK | CK1 | 6cfm | A | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9718 | 0.43 | |
| VRK1 | VRK | CK1 | 6bru | D | A | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one | Human | 9084 | 0.45 | |
| VRK1 | VRK | CK1 | 6cqh | B | B | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9770 | 0.42 | |
| VRK1 | VRK | CK1 | 6cqh | B | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9769 | 0.42 | |
| VRK1 | VRK | CK1 | 6cqh | A | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one | Human | 9774 | 0.42 | |
| VRK1 | VRK | CK1 | 6btw | B | A | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one | Human | 9424 | 1.00 | |
| VRK1 | VRK | CK1 | 6btw | A | A | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one | Human | 9418 | 1.00 | |
| VRK1 | VRK | CK1 | 6btw | B | B | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one | Human | 9411 | 1.00 | |
| VRK1 | VRK | CK1 | 6btw | D | B | 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one | Human | 9420 | 1.00 | |
| VRK1 | VRK | CK1 | 6bru | D | B | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one | Human | 9083 | 0.45 | |
| VRK1 | VRK | CK1 | 6dd4 | B | A | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5h)-one | Human | 9937 | 0.41 | |
| VRK1 | VRK | CK1 | 5uvf | C | | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 7520 | 0.40 | |
