| EPHA2 (EphA2) | Eph | TK | 6q7f | A | B | 3-[(4-imidazol-1-yl-6-piperazin-1-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11936 | 0.41 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | A | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11933 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | C | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11934 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | B | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11938 | 0.40 | |
| BRAF | RAF | TKL | 5vam | B | A | n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | Human | 8186 | 0.41 | |
| EPHA2 (EphA2) | Eph | TK | 6q7e | A | B | 3-[[4-imidazol-1-yl-6-[(3~{r})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11932 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6q7f | A | A | 3-[(4-imidazol-1-yl-6-piperazin-1-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11929 | 0.41 | |
| EPHA2 (EphA2) | Eph | TK | 6q7e | A | A | 3-[[4-imidazol-1-yl-6-[(3~{r})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11926 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6q7b | A | A | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11927 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6q7b | A | B | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11935 | 0.40 | |
| STK10 (LOK) | STE20 | STE | 4equ | B | A | n-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 941 | 0.40 | |
| LCK | Src | TK | 2ofv | A | | 3-(2-aminoquinazolin-6-yl)-4-methyl-n-[3-(trifluoromethyl)phenyl]benzamide | Human | 2280 | 0.42 | |
| TNK2 (ACK) | Ack | TK | 5zxb | A | A | n-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 10492 | 1.00 | |
| STK10 (LOK) | STE20 | STE | 4equ | A | B | n-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 938 | 0.40 | |
| TNK2 (ACK) | Ack | TK | 5zxb | A | B | n-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 10494 | 1.00 | |
| BRAF | RAF | TKL | 6b8u | A | | ~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | Human | 8679 | 0.40 | |
| FGFR4 | FGFR | TK | 4qqc | A | A | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 934 | 0.40 | |
| FGFR4 | FGFR | TK | 4qqc | A | B | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 932 | 0.40 | |
| ABL1 | Abl | TK | 2hiw | B | | 7-amino-1-methyl-3-(2-methyl-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-2-oxo-2,3-dihydropyrimido[4,5-d]pyrimidin-1-ium | Human | 1110 | 0.70 | |
| SYK | Syk | TK | 3tud | A | | n-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide | Human | 1176 | 0.49 | |
| TNK2 (ACK) | Ack | TK | 5zxb | B | A | n-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 10493 | 1.00 | |
| BRAF | RAF | TKL | 5vam | B | B | n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | Human | 8187 | 0.41 | |
| BRAF | RAF | TKL | 6n0q | B | A | n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 11770 | 0.41 | |
| BRAF | RAF | TKL | 6b8u | B | | ~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | Human | 8678 | 0.40 | |
| BRAF | RAF | TKL | 6n0q | A | B | n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 11768 | 0.41 | |
| BRAF | RAF | TKL | 5vam | A | B | n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | Human | 8189 | 0.41 | |
| MAPK14 (p38a) | MAPK | CMGC | 5mz3 | A | B | ~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | Human | 8681 | 0.40 | |
| MAPK14 (p38a) | MAPK | CMGC | 5mz3 | A | A | ~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | Human | 8680 | 0.40 | |
| BRAF | RAF | TKL | 6n0q | A | A | n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 11771 | 0.41 | |
| FGFR4 | FGFR | TK | 4qq5 | A | | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 921 | 0.40 | |
| TNK2 (ACK) | Ack | TK | 5zxb | B | B | n-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 10495 | 1.00 | |
| BRAF | RAF | TKL | 6n0q | B | B | n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 11769 | 0.41 | |
| LCK | Src | TK | 3byu | A | | 2-methyl-n-{4-methyl-3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)carbamoyl]phenyl}-3-(trifluoromethyl)benzamide | Human | 2288 | 0.42 | |
| LCK | Src | TK | 3bys | A | | 4-methyl-n~3~-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)-n~1~-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide | Human | 2293 | 0.53 | |
| LCK | Src | TK | 2ofv | B | | 3-(2-aminoquinazolin-6-yl)-4-methyl-n-[3-(trifluoromethyl)phenyl]benzamide | Human | 2294 | 0.42 | |
| ABL1 | Abl | TK | 2hiw | A | | 7-amino-1-methyl-3-(2-methyl-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-2-oxo-2,3-dihydropyrimido[4,5-d]pyrimidin-1-ium | Human | 1069 | 0.70 | |
| STK10 (LOK) | STE20 | STE | 4equ | A | A | n-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 957 | 0.40 | |
| STK10 (LOK) | STE20 | STE | 4equ | B | B | n-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 959 | 0.40 | |
| BRAF | RAF | TKL | 5vam | A | A | n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | Human | 8185 | 0.41 | |
