| MAP4K1 (HPK1) | STE20 | STE | 7m0k | B | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13470 | 0.41 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | D | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13471 | 0.41 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | C | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13474 | 0.41 | |
| TBK1 | IKK | Other | 4im0 | A | B | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 607 | 0.63 | |
| TBK1 | IKK | Other | 4euu | A | A | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 615 | 0.40 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | D | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13479 | 0.41 | |
| TBK1 | IKK | Other | 4eut | A | B | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 621 | 0.40 | |
| TBK1 | IKK | Other | 4iwq | A | | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 605 | 0.63 | |
| PDPK1 (PDK1) | PDK1 | AGC | 1z5m | A | | n-(3-{[5-bromo-2-({3-[(pyrrolidin-1-ylcarbonyl)amino]phenyl}amino)pyrimidin-4-yl]amino}propyl)-2,2-dimethylmalonamide | Human | 3152 | 0.41 | |
| TBK1 | IKK | Other | 4eut | A | A | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 609 | 0.40 | |
| STK24 (MST3) | STE20 | STE | 4qmv | A | | n-{2-[(1s,4r)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide | Human | 5581 | 0.40 | |
| ULK1 | ULK | Other | 6qas | B | A | n-{2-[(1s,4r)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide | Human | 10932 | 0.40 | |
| ULK1 | ULK | Other | 6qas | A | B | n-{2-[(1s,4r)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide | Human | 10931 | 0.40 | |
| ULK1 | ULK | Other | 6qas | A | A | n-{2-[(1s,4r)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide | Human | 10930 | 0.40 | |
| TBK1 | IKK | Other | 4euu | B | A | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 606 | 0.40 | |
| JAK2 | JakA | TK | 6vnf | B | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13346 | 0.44 | |
| JAK2 | JakA | TK | 6vnf | A | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13347 | 0.44 | |
| TBK1 | IKK | Other | 4iwp | A | | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 612 | 0.40 | |
| TBK1 | IKK | Other | 4im2 | A | A | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 620 | 0.40 | |
| TBK1 | IKK | Other | 4euu | B | B | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 616 | 0.40 | |
| TBK1 | IKK | Other | 4im2 | A | B | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 613 | 0.40 | |
| TBK1 | IKK | Other | 4euu | A | B | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 611 | 0.40 | |
| TBK1 | IKK | Other | 4iw0 | A | | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 608 | 0.40 | |
| TBK1 | IKK | Other | 4im3 | A | B | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 622 | 0.40 | |
| TBK1 | IKK | Other | 6o8b | A | | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 11053 | 0.40 | |
| TBK1 | IKK | Other | 4eut | B | A | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 618 | 0.40 | |
| TBK1 | IKK | Other | 4eut | B | B | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 617 | 0.40 | |
| TBK1 | IKK | Other | 6o8b | B | | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 11054 | 0.40 | |
| TBK1 | IKK | Other | 4im0 | A | A | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 610 | 0.63 | |
| TBK1 | IKK | Other | 4im3 | A | A | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Human | 619 | 0.40 | |
| ULK2 | ULK | Other | 6qau | B | B | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 11236 | 0.63 | |
| ULK2 | ULK | Other | 6qav | A | A | ~{n}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{h}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | Human | 11231 | 1.00 | |
| ULK2 | ULK | Other | 6qau | C | B | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 11233 | 0.63 | |
| ULK2 | ULK | Other | 6qau | A | B | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 11225 | 0.63 | |
| ULK2 | ULK | Other | 6qau | A | A | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 11235 | 0.63 | |
| ULK2 | ULK | Other | 6qav | B | A | ~{n}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{h}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | Human | 11224 | 1.00 | |
| JAK2 | JakA | TK | 6vnf | A | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13357 | 0.44 | |
| ULK1 | ULK | Other | 6qas | B | B | n-{2-[(1s,4r)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide | Human | 10933 | 0.40 | |
| WEE1 (Wee1) | WEE | Other | 5vd2 | A | | n-{2-[(1s,4r)-6-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl]-2-oxoethyl}acetamide | Human | 8330 | 0.40 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | C | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13473 | 0.41 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | A | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13480 | 0.41 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | A | B | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13481 | 0.41 | |
| ULK2 | ULK | Other | 6qav | D | B | ~{n}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{h}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | Human | 11238 | 1.00 | |
| ULK2 | ULK | Other | 6qav | C | B | ~{n}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{h}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | Human | 11228 | 1.00 | |
| ULK2 | ULK | Other | 6qau | C | A | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 11229 | 0.63 | |
| ULK2 | ULK | Other | 6qav | B | B | ~{n}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{h}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | Human | 11237 | 1.00 | |
| TBK1 | IKK | Other | 4iwo | A | | n-{3-[(5-cyclopropyl-2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 614 | 0.67 | |
| MAP4K1 (HPK1) | STE20 | STE | 7m0k | B | A | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | Human | 13476 | 0.41 | |
| JAK2 | JakA | TK | 6vnf | B | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13352 | 0.44 | |
| ULK2 | ULK | Other | 6qau | B | A | n-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | Human | 11222 | 0.63 | |
| ULK2 | ULK | Other | 6qav | A | B | ~{n}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{h}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | Human | 11239 | 1.00 | |
| ULK2 | ULK | Other | 6qav | D | A | ~{n}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{h}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | Human | 11234 | 1.00 | |
| ULK2 | ULK | Other | 6qav | C | A | ~{n}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{h}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | Human | 11223 | 1.00 | |
| Tbk1 (TBK1) | IKK | Other | 6o8c | A | B | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Mouse | 11302 | 0.40 | |
| Tbk1 (TBK1) | IKK | Other | 6o8c | A | A | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Mouse | 11303 | 0.40 | |
| Tbk1 (TBK1) | IKK | Other | 4jl9 | A | | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Mouse | 5697 | 0.40 | |
| Tbk1 (TBK1) | IKK | Other | 6o8c | B | A | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Mouse | 11305 | 0.40 | |
| Tbk1 (TBK1) | IKK | Other | 6o8c | B | B | n-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | Mouse | 11304 | 0.40 | |
