| TYK2-b | JakB | TK | 7k7o | A | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 13835 | 0.48 | |
| TYK2-b | JakB | TK | 7k7q | A | B | 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamide | Human | 13836 | 0.41 | |
| TYK2-b | JakB | TK | 6nzr | B | B | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11500 | 0.55 | |
| TYK2-b | JakB | TK | 6nzf | B | A | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11451 | 0.74 | |
| TYK2-b | JakB | TK | 7k7o | A | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 13837 | 0.48 | |
| TYK2-b | JakB | TK | 6nzq | A | B | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11499 | 0.42 | |
| TYK2-b | JakB | TK | 6nzh | B | A | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11447 | 1.00 | |
| TYK2-b | JakB | TK | 6nzr | A | B | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11503 | 0.55 | |
| TYK2-b | JakB | TK | 8tb5 | A | B | n-{(3p)-3-[3-(dimethylsulfamoyl)phenyl]-1h-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide | Human | 14955 | 0.41 | |
| TYK2-b | JakB | TK | 6nze | A | B | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11444 | 0.52 | |
| TYK2-b | JakB | TK | 6nzp | B | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11496 | 0.45 | |
| TYK2-b | JakB | TK | 6nzq | B | A | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11495 | 0.42 | |
| TYK2-b | JakB | TK | 6nzf | A | B | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11449 | 0.74 | |
| TYK2-b | JakB | TK | 8tb5 | A | A | n-{(3p)-3-[3-(dimethylsulfamoyl)phenyl]-1h-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide | Human | 14958 | 0.41 | |
| MAPK1 (Erk2) | MAPK | CMGC | 4zzn | A | B | 2-[[5-chloranyl-2-(oxan-4-ylamino)pyridin-4-yl]amino]-n-methyl-benzamide | Human | 2610 | 0.45 | |
| TYK2-b | JakB | TK | 6nzp | A | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11501 | 0.45 | |
| TYK2-b | JakB | TK | 6nzr | A | A | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11505 | 0.55 | |
| MAPK1 (Erk2) | MAPK | CMGC | 4zzn | A | A | 2-[[5-chloranyl-2-(oxan-4-ylamino)pyridin-4-yl]amino]-n-methyl-benzamide | Human | 2605 | 0.45 | |
| TYK2-b | JakB | TK | 6nzh | A | A | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11450 | 1.00 | |
| TYK2-b | JakB | TK | 6nzf | B | B | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11445 | 0.74 | |
| TYK2-b | JakB | TK | 6nzh | B | B | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11452 | 1.00 | |
| TYK2-b | JakB | TK | 6nzh | A | B | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11442 | 1.00 | |
| TYK2-b | JakB | TK | 6nzp | B | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11497 | 0.45 | |
| TYK2-b | JakB | TK | 6nze | A | A | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11453 | 0.52 | |
| TYK2-b | JakB | TK | 6nzr | B | A | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11498 | 0.55 | |
| TYK2-b | JakB | TK | 6nzq | A | A | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11502 | 0.42 | |
| TYK2-b | JakB | TK | 4oli | A | | 2-chloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 2198 | 0.42 | |
| TYK2-b | JakB | TK | 6nze | B | A | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11448 | 0.52 | |
| TYK2-b | JakB | TK | 6nzf | A | A | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11446 | 0.74 | |
| TYK2-b | JakB | TK | 7k7q | A | A | 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamide | Human | 13838 | 0.41 | |
| TYK2-b | JakB | TK | 6nzq | B | B | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11506 | 0.42 | |
| TYK2-b | JakB | TK | 6nze | B | B | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11443 | 0.52 | |
| TYK2-b | JakB | TK | 6nzp | A | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11504 | 0.45 | |
