| SYK | Syk | TK | 1xbb | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1184 | 0.43 | |
| JAK2 | JakA | TK | 4bbe | B | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3727 | 0.41 | |
| LCK | Src | TK | 4c3f | A | B | n-phenyl-4-(5-phenyl-1h-pyrazol-4-yl)pyrimidin-2-amine | Human | 2297 | 0.43 | |
| LCK | Src | TK | 4c3f | A | A | n-phenyl-4-(5-phenyl-1h-pyrazol-4-yl)pyrimidin-2-amine | Human | 2276 | 0.43 | |
| LCK | Src | TK | 2pl0 | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 2290 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3mss | C | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5719 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 1fpu | A | | n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamide | Mouse | 5728 | 0.42 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10611 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 1iep | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5703 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5723 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3mss | D | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5702 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 1fpu | B | | n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamide | Mouse | 5705 | 0.42 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10608 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 1iep | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5727 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 1opj | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5736 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10609 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5706 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5734 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10610 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3mss | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5724 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3mss | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5730 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5722 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5733 | 0.43 | |
| ABL1 | Abl | TK | 6npu | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10942 | 0.43 | |
| CDK2 | CDK | CMGC | 2xnb | A | A | 3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-one | Human | 4217 | 0.47 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 6jol | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 12103 | 0.43 | |
| ABL2 | Abl | TK | 3gvu | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 109 | 0.43 | |
| AURKA (AurA) | Aur | Other | 2xne | A | | 3-chloro-n-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine | Human | 7221 | 0.40 | |
| ABL1 | Abl | TK | 2hyy | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1078 | 0.43 | |
| CDK2 | CDK | CMGC | 2xnb | A | B | 3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-one | Human | 4034 | 0.47 | |
| ABL1 | Abl | TK | 6npv | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10950 | 0.43 | |
| ACVR1 (ALK2) | STKR | TKL | 6jux | A | A | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | Human | 12161 | 1.00 | |
| ABL1 | Abl | TK | 2hyy | D | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1068 | 0.43 | |
| ABL1 | Abl | TK | 6npv | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10951 | 0.43 | |
| MAPK1 (Erk2) | MAPK | CMGC | 5ngu | A | | 2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | Human | 7991 | 0.44 | |
| SYK | Syk | TK | 1xbb | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1196 | 0.43 | |
| ABL1 | Abl | TK | 3pyy | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1062 | 0.43 | |
| ABL1 | Abl | TK | 6npu | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10944 | 0.43 | |
| JAK2 | JakA | TK | 4bbe | C | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3649 | 0.41 | |
| DDR1 | DDR | TK | 4bkj | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3263 | 0.43 | |
| ABL1 | Abl | TK | 2hyy | C | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1048 | 0.43 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13390 | 0.53 | |
| DDR1 | DDR | TK | 4bkj | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3256 | 0.43 | |
| DDR1 | DDR | TK | 4bkj | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3259 | 0.43 | |
| ABL1 | Abl | TK | 6npv | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10948 | 0.43 | |
| CSF1R (FMS) | PDGFR | TK | 4r7i | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 2307 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5708 | 0.43 | |
| ACVR1 (ALK2) | STKR | TKL | 6jux | A | B | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | Human | 12160 | 1.00 | |
| KIT | PDGFR | TK | 1t46 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 393 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10645 | 0.43 | |
| JAK2 | JakA | TK | 4bbe | A | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3670 | 0.41 | |
| ABL1 | Abl | TK | 3pyy | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1071 | 0.43 | |
| DDR1 | DDR | TK | 4bkj | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3255 | 0.43 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hec | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 5166 | 0.43 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hec | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 5035 | 0.43 | |
| ACVR1 (ALK2) | STKR | TKL | 6acr | A | | n-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1h-pyrazol-4-yl]pyrimidin-2-amine | Human | 10969 | 0.53 | |
| ACVR1 (ALK2) | STKR | TKL | 6acr | B | | n-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1h-pyrazol-4-yl]pyrimidin-2-amine | Human | 10968 | 0.53 | |
| ABL1 | Abl | TK | 6npe | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10943 | 0.43 | |
| JAK2 | JakA | TK | 4bbe | D | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3726 | 0.41 | |
| KIT | PDGFR | TK | 1t46 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 404 | 0.43 | |
| ABL1 | Abl | TK | 6npv | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10949 | 0.43 | |
| ABL1 | Abl | TK | 3pyy | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1049 | 0.43 | |
| CDK2 | CDK | CMGC | 2vv9 | A | A | 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol | Human | 3989 | 0.40 | |
| CDK2 | CDK | CMGC | 2vv9 | A | B | 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol | Human | 3881 | 0.40 | |
| ABL1 | Abl | TK | 6npe | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10945 | 0.43 | |
| ABL1 | Abl | TK | 2hyy | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1092 | 0.43 | |
| ABL1 | Abl | TK | 6npe | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10946 | 0.43 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13389 | 0.53 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13391 | 0.53 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13392 | 0.53 | |
| ABL2 | Abl | TK | 3gvu | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 117 | 0.43 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3kvx | A | A | n-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)aniline | Human | 3433 | 0.40 | |
| ABL1 | Abl | TK | 3pyy | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1098 | 0.43 | |
| ABL1 | Abl | TK | 6npe | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10947 | 0.43 | |
| SRC | Src | TK | 1y57 | A | | 4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide | Human | 986 | 0.40 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3kvx | A | B | n-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)aniline | Human | 3430 | 0.40 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5713 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 1opj | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5732 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10648 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10646 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10647 | 0.43 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5710 | 0.43 | |
