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Search results (54 entries covering 20 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
VRK1VRKCK13op5AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48700.45
CAMK2B (CaMK2b)CAMK2CAMK3bhhB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrileHuman15060.45
CAMK2B (CaMK2b)CAMK2CAMK3bhhA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrileHuman15070.45
PAK4STE20STE5xvgA[6-chloranyl-4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3r)-3-methylpiperazin-1-yl]methanoneHuman95510.40
CDK2CDKCMGC4ek5ABn-(5-cyclopropyl-1h-pyrazol-3-yl)benzene-1,4-dicarboxamideHuman41450.40
CDK2CDKCMGC1vywCn-(3-cyclopropyl-1h-pyrazol-5-yl)-2-(2-naphthyl)acetamideHuman41330.40
MAP2K7STE7STE6yg5A[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrileHuman126770.75
STK17B (DRAK2)DAPKCAMK3lm0AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-5-methylpyrimidin-2-yl}amino)phenyl]acetonitrileHuman67960.48
STK17B (DRAK2)DAPKCAMK3lm0AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-5-methylpyrimidin-2-yl}amino)phenyl]acetonitrileHuman67970.48
ULK1ULKOther4wnpCBn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18730.68
ULK1ULKOther4wnpABn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18740.68
VRK1VRKCK13op5CA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48860.45
MAPK1 (Erk2)MAPKCMGC4fv8AB6-({4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]-5-(phenylamino)pyrimidin-2-yl}amino)-1,2-dihydro-3h-indazol-3-oneHuman26010.42
ACVR2A (ACTR2)STKRTKL3socAB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26760.75
SLKSTE20STE2uv2AA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18340.75
ULK1ULKOther4wnpAAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18780.68
ULK1ULKOther4wnoABn~2~-(4-aminophenyl)-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18761.00
VRK1VRKCK13op5DB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48920.45
SLKSTE20STE2uv2AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18370.75
SYKSykTK5t68Bn~4~-cyclopropyl-n~2~-(3-methyl-1h-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamineHuman71200.41
SYKSykTK5t68An~4~-cyclopropyl-n~2~-(3-methyl-1h-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamineHuman71190.41
ACVR2A (ACTR2)STKRTKL3socBA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26770.75
STK26 (MST4)STE20STE3ggfBB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18040.75
ULK1ULKOther4wnpBBn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18790.68
ULK1ULKOther4wnoAAn~2~-(4-aminophenyl)-n~4~-(5-cyclopropyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18811.00
ULK1ULKOther4wnpBAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18720.68
ULK1ULKOther4wnpDBn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18800.68
PAK1STE20STE4zy4A2-(4-aminopiperidin-1-yl)-n-(5-cyclopropyl-1h-pyrazol-3-yl)thieno[3,2-d]pyrimidin-4-amineHuman1870.41
VRK1VRKCK13op5DA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48780.45
CDK2CDKCMGC1vyzAn-(5-cyclopropyl-1h-pyrazol-3-yl)benzamideHuman43250.44
VRK1VRKCK13op5CB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48790.45
STK26 (MST4)STE20STE3ggfAB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18080.75
PAK1STE20STE4zy4B2-(4-aminopiperidin-1-yl)-n-(5-cyclopropyl-1h-pyrazol-3-yl)thieno[3,2-d]pyrimidin-4-amineHuman1540.41
CDK2CDKCMGC4ek5AAn-(5-cyclopropyl-1h-pyrazol-3-yl)benzene-1,4-dicarboxamideHuman40370.40
CAMK1D (CaMK1d)CAMK1CAMK2jc6ABn-(5-methyl-1h-pyrazol-3-yl)-2-phenylquinazolin-4-amineHuman48300.46
MAPK1 (Erk2)MAPKCMGC4fv8AA6-({4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]-5-(phenylamino)pyrimidin-2-yl}amino)-1,2-dihydro-3h-indazol-3-oneHuman26250.42
ULK4ULKOther6u5lABn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman118890.68
VRK1VRKCK13op5BA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman48940.45
AURKA (AurA)AurOther4j8mA1-[4-[[4-[(5-cyclopentyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]ureaHuman20200.40
CDK2CDKCMGC1vywAn-(3-cyclopropyl-1h-pyrazol-5-yl)-2-(2-naphthyl)acetamideHuman39920.40
CAMK2D (CaMK2d)CAMK2CAMK2vn9A[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman21400.75
CAMK2D (CaMK2d)CAMK2CAMK2vn9B[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman21390.75
ACVR2A (ACTR2)STKRTKL3socAA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26750.75
ACVR2A (ACTR2)STKRTKL3socBB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman26850.75
CAMK1D (CaMK1d)CAMK1CAMK2jc6CAn-(5-methyl-1h-pyrazol-3-yl)-2-phenylquinazolin-4-amineHuman48320.46
CAMK1D (CaMK1d)CAMK1CAMK2jc6CBn-(5-methyl-1h-pyrazol-3-yl)-2-phenylquinazolin-4-amineHuman48310.46
CAMK1D (CaMK1d)CAMK1CAMK2jc6AAn-(5-methyl-1h-pyrazol-3-yl)-2-phenylquinazolin-4-amineHuman48290.46
STK26 (MST4)STE20STE3ggfAA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18070.75
STK26 (MST4)STE20STE3ggfBA[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrileHuman18050.75
ULK4ULKOther6u5lAAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman118900.68
ULK1ULKOther4wnpDAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18750.68
ULK1ULKOther4wnpCAn~2~-(1h-benzimidazol-6-yl)-n~4~-(5-cyclobutyl-1h-pyrazol-3-yl)quinazoline-2,4-diamineHuman18770.68
VRK1VRKCK13op5BB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman49440.45
VRK1VRKCK13op5AB[4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrileHuman49420.45
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