| MLKL | TKL-Unique | TKL | 7mon | A | | n-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 13980 | 0.46 | |
| JAK2 | JakA | TK | 5wev | A | A | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8377 | 0.41 | |
| GSK3B | GSK | CMGC | 4ptg | A | A | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide | Human | 735 | 0.44 | |
| GSK3B | GSK | CMGC | 8djd | A | A | 2-[(cyclopropanecarbonyl)amino]-n-(5-phenylpyridin-3-yl)pyridine-4-carboxamide | Human | 14673 | 0.53 | |
| GSK3B | GSK | CMGC | 4pte | B | A | n-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide | Human | 722 | 0.47 | |
| TYK2-b | JakB | TK | 6nzh | B | A | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11447 | 0.42 | |
| GSK3B | GSK | CMGC | 4ptg | B | B | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide | Human | 754 | 0.44 | |
| GSK3B | GSK | CMGC | 8djd | A | B | 2-[(cyclopropanecarbonyl)amino]-n-(5-phenylpyridin-3-yl)pyridine-4-carboxamide | Human | 14668 | 0.53 | |
| PRKCI (PKCi) | PKC | AGC | 6ilz | E | | 2-amino-5-[3-(piperazin-1-yl)phenyl]-n-(pyridin-4-yl)pyridine-3-carboxamide | Human | 11356 | 0.40 | |
| RIPK3 | RIPK | TKL | 7mon | B | | n-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 13979 | 0.46 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5fri | A | B | n-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide | Human | 6893 | 0.57 | |
| ROCK1 | DMPK | AGC | 2etr | B | | (r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) cyclohexanecarboxamide | Human | 2704 | 0.46 | |
| JAK2 | JakA | TK | 4gmy | A | | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3684 | 0.77 | |
| TYK2 | JakA | TK | 4gih | A | A | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3339 | 0.77 | |
| GSK3B | GSK | CMGC | 4ptg | A | B | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide | Human | 634 | 0.44 | |
| AURKA (AurA) | Aur | Other | 2np8 | A | | n-{3-[(4-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]phenyl}cyclopropanecarboxamide | Human | 2075 | 0.45 | |
| ROCK1 | DMPK | AGC | 2etr | A | | (r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) cyclohexanecarboxamide | Human | 2700 | 0.46 | |
| GSK3B | GSK | CMGC | 4pte | A | A | n-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide | Human | 716 | 0.47 | |
| GSK3B | GSK | CMGC | 4ptc | A | A | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide | Human | 664 | 0.43 | |
| TYK2-b | JakB | TK | 6nzh | A | A | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11450 | 0.42 | |
| TYK2-b | JakB | TK | 6nzh | B | B | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11452 | 0.42 | |
| GSK3B | GSK | CMGC | 5f95 | A | | 2-[(cyclopropylcarbonyl)amino]-n-(4-phenylpyridin-3-yl)pyridine-4-carboxamide | Human | 6373 | 0.49 | |
| JAK2 | JakA | TK | 5wev | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8376 | 0.41 | |
| TYK2-b | JakB | TK | 6nzh | A | B | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11442 | 0.42 | |
| GSK3B | GSK | CMGC | 4ptc | B | A | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide | Human | 747 | 0.43 | |
| GSK3B | GSK | CMGC | 4pte | A | B | n-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide | Human | 717 | 0.47 | |
| GSK3B | GSK | CMGC | 5f94 | B | B | 2-[(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4-carboxamide | Human | 6371 | 0.45 | |
| PRKCI (PKCi) | PKC | AGC | 6ilz | A | | 2-amino-5-[3-(piperazin-1-yl)phenyl]-n-(pyridin-4-yl)pyridine-3-carboxamide | Human | 11358 | 0.40 | |
| PRKCI (PKCi) | PKC | AGC | 6ilz | G | | 2-amino-5-[3-(piperazin-1-yl)phenyl]-n-(pyridin-4-yl)pyridine-3-carboxamide | Human | 11355 | 0.40 | |
| GSK3B | GSK | CMGC | 4ptg | B | A | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide | Human | 740 | 0.44 | |
| TYK2-b | JakB | TK | 4oli | A | | 2-chloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 2198 | 1.00 | |
| GSK3B | GSK | CMGC | 5f94 | A | B | 2-[(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4-carboxamide | Human | 6369 | 0.45 | |
| GSK3B | GSK | CMGC | 4ptc | B | B | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide | Human | 758 | 0.43 | |
| GSK3B | GSK | CMGC | 5f94 | A | A | 2-[(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4-carboxamide | Human | 6374 | 0.45 | |
| GSK3B | GSK | CMGC | 4pte | B | B | n-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide | Human | 667 | 0.47 | |
| GSK3B | GSK | CMGC | 5f95 | B | | 2-[(cyclopropylcarbonyl)amino]-n-(4-phenylpyridin-3-yl)pyridine-4-carboxamide | Human | 6370 | 0.49 | |
| GSK3B | GSK | CMGC | 4ptc | A | B | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-oxo-4h-1lambda~4~,3-thiazole-5-carboxamide | Human | 659 | 0.43 | |
| TYK2 | JakA | TK | 4gj3 | A | | 2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | Human | 3345 | 0.49 | |
| TYK2 | JakA | TK | 5wal | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8374 | 0.41 | |
| TYK2 | JakA | TK | 4gj2 | A | | 2,6-dichloro-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | Human | 3344 | 0.60 | |
| TYK2 | JakA | TK | 4gih | A | B | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3332 | 0.77 | |
| TYK2 | JakA | TK | 4gii | A | | 2,6-dichloro-4-cyano-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3331 | 0.65 | |
| GSK3B | GSK | CMGC | 5f94 | B | A | 2-[(cyclopropylcarbonyl)amino]-n-(4-methoxypyridin-3-yl)pyridine-4-carboxamide | Human | 6372 | 0.45 | |
| TYK2 | JakA | TK | 5wal | A | A | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8375 | 0.41 | |
| MAPK10 (JNK3) | MAPK | CMGC | 2exc | X | | n-{2'-[(4-fluorophenyl)amino]-4,4'-bipyridin-2-yl}-4-methoxycyclohexanecarboxamide | Human | 3478 | 0.44 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5fri | A | A | n-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide | Human | 6894 | 0.57 | |
| RPS6KB1 (p70S6K) | RSK | AGC | 3wf7 | A | B | 1-(9h-purin-6-yl)-n-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide | Human | 1851 | 0.41 | |
| RPS6KB1 (p70S6K) | RSK | AGC | 3wf7 | A | A | 1-(9h-purin-6-yl)-n-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide | Human | 1854 | 0.41 | |
| PRKCI (PKCi) | PKC | AGC | 6ilz | C | | 2-amino-5-[3-(piperazin-1-yl)phenyl]-n-(pyridin-4-yl)pyridine-3-carboxamide | Human | 11357 | 0.40 | |
